Results 41 to 50 of about 275,015 (270)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A prospective study on the effectiveness of a combination regime (Mifepristone and Misoprostol) in comparison with Misoprostol for missed abortion

Journal of Family Medicine and Primary Care, 2023
Introduction: Misoprostol is widely used in the medical management of missed abortions. However, pretreatment with Mifepristone has shown to be effective but still not recommended to be used in missed abortions.
Nidhi Gupta, Reva Tripathi, Sumedha Sharma, Aruna Nigam, Sanjeet Panesar   +4 more
doaj   +1 more source

Influence of the sample geometry on the vortex matter in superconducting microstructures

, 2004
The dependence of the vortex penetration and expulsion on the geometry of mesoscopic superconductors is reported. Hall magnetometry measurements were performed on a superconducting Al square and triangle.
I. S. Ibrahim, Joost Bekaert, Mathieu Morelle, V. R. Misko, V. V. Moshchalkov, Victor V. Moshchalkov   +5 more
core   +1 more source

The effect of the dynamical state of clusters on gas expulsion and infant mortality [PDF]

, 2008
The star formation efficiency (SFE) of a star cluster is thought to be the critical factor in determining if the cluster can survive for a significant (>50 Myr) time.
A.-K. Jappsen, B.C. Whitmore, B.G. Elmegreen, B.G. Elmegreen, B.G. Elmegreen, C.J. Lada, C.J. Lada, C.M. Boily, C.M. Boily, F. Pinto, G. Parmentier, H. Baumgardt, H. Baumgardt, J.G. Hills, M. Gieles, M.P. Gyer, N. Bastian, N. Bastian, P. Kroupa, P. Padoan, P. Padoan, R. Chandar, R. Grijs de, R.D. Mathieu, R.S. Klessen, R.S. Klessen, S.P. Goodwin, S.P. Goodwin, S.P. Goodwin, Simon P. Goodwin, W. Verschueren, W. Verschueren, Y. Li   +32 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The determinants of earlier extraction of IUD in women under rural health care centers, Babol

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2003
Background and Objective: In using IUD as an intrauterine device, an important problem is earlier extraction, which reduces the rate of its efficacy. The objective of this study was to explain the determinants of earlier extraction of IUD.
K Hajian, M Zeinal Zadeh, NM Jafari Chogani   +2 more
doaj  

Evolution dynamics with the switching strategy of punishment and expulsion in the spatial public goods game

New Journal of Physics, 2022
Punishment and expulsion are two different strategies to promote cooperation with altruistic sanctions. Of them, expulsion is usually considered more severe and effective than punishment as a strategy to expel a traitor from the field directly.
Siqing Zhuo, Jie Liu, Tianyu Ren, Jiayi Sun   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source