Results 61 to 70 of about 683,134 (295)

Application of Extended Care in Antiviral Therapy for Elderly Patients with Acquired Immunodeficiency Syndrome

open access: yesGuoji laonian yixue zazhi
Objective To explore the effect of extended care on improving the compliance, efficacy and quality of life of antiviral therapy in elderly patients with acquired immunodeficiency syndrome (AIDS) .
Zhangli Wang   +4 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Research progress of extended care in elderly patients with chronic diseases (老年慢性病患者延续性护理的研究进展)

open access: yes中西医结合护理
The extended care service plays an important role in improving the condition and quality of life of elderly patients with chronic diseases. This paper introduced the concept of extended care, and summarized the ways of extended care service for elderly ...
BI Xiaolu (毕晓露)   +1 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Extending out-of-home care in the state of Victoria, Australia: the policy context and outcomes

open access: yesScottish Journal of Residential Child Care, 2021
In November 2020, the State (Labour Party) Government of Victoria in Australia announced that it would extend out-of-home care (OOHC) on a universal basis until 21 years of age starting 1 January 2021.
Philip Mendes
doaj   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Establishment and implementation of the Refractory Pain Care Studio (难治性疼痛护理工作室的建立与实施)

open access: yes中西医结合护理
Refractory pain seriously affects patients' mental, psychological and quality of life, and leads to heavy family and socio-economic burdens. The Refractory Pain Care Studio has a multidisciplinary working model and a diversified project management system,
SONG Qian (宋倩)   +1 more
doaj   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

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