Results 41 to 50 of about 71,006 (311)

Generating French virtual commuting networks at the municipality level

Journal of Transport and Land Use, 2014
We aim to generate virtual commuting networks in the rural regions of France in order to study the dynamics of their municipalities. Since it will be necessary to model small commuting flows between municipalities with a few hundred or thousand ...
Maxime Lenormand, Sylvie Huet, Floriana Gargiulo   +2 more
doaj   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Deterring a Nuclear Iran: The Devil in the Details [PDF]

, 2010
Explores the technical requirements for a deterrence regime against Iran should it acquire a nuclear weapons capability. Considers red lines, treaty arrangements, force deployment and bases, military assistance to Iran's neighbors, and crisis ...
Kenneth M. Pollack
core  

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Extended Deterrence Dilemmas in the Grey Zone: Trans-Atlantic Insights on Baltic Security Challenges1

Journal on Baltic Security, 2019
Should the U.S. respond with military means to a limited Russian incursion in the Baltics? This paper explores Western attitudes towards such a hypothetical grey zone crisis. Using survey experiments and crisis simulations we find considerable reluctance
Murauskaite Egle, Quinn David, Thomson Catarina P., Ellis Devin H., Wilkenfeld Jonathan, Gartzke Erik   +5 more
doaj   +1 more source

Customer mobility and congestion in supermarkets

, 2019
The analysis and characterization of human mobility using population-level mobility models is important for numerous applications, ranging from the estimation of commuter flows in cities to modeling trade flows between countries.
Beguerisse-Díaz, Mariano, Howison, Sam D., Porter, Mason A., Wallis, Alisdair O. G., Ying, Fabian   +4 more
core   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Ultrasound‐Responsive Engineered Bacteria for Targeted Cancer Therapy: Strategies, Mechanisms, and Applications

Advanced Science, EarlyView.
This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang, Wenjing Xu, Yafang Lu, Huaibin Yu, Zhengbao Zha, Xijun Zhang   +5 more
wiley   +1 more source

Towards a French nuclear umbrella? Assessing the transition from US to French dual-key arrangements

European Journal of International Security
The potential withdrawal of the United States from European security commitments has raised questions about the future of nuclear deterrence on the continent.
Nicolás Bardio
doaj   +1 more source

Designing Cost‐Effective Carbon Payments to Induce Cellulosic Feedstock Production for Sustainable Aviation Fuel

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Perennial bioenergy crops, such as miscanthus and switchgrass, and crop residues have the potential to scale up sustainable aviation fuel (SAF) production and mitigate carbon emissions. However, high establishment costs, delayed returns, and risk–return profiles that diverge from those of conventional crops can hinder incentives to adopt ...
Fahd Majeed, Madhu Khanna, Ruiqing Miao
wiley   +1 more source