Results 221 to 230 of about 40,502 (261)

The Role of the Gut Microbiome in the Complex Network of Frailty Syndrome and Associated Comorbidities in Aging

Aging Cell, Volume 25, Issue 2, February 2026.
This study analyzed gut microbiota in older adults with and without Frailty Syndrome by 16S rRNA gene sequencing and metagenomics. Frailty was associated with altered microbial composition, metabolic functions, and increased antimicrobial resistance, whereas non‐frail individuals showed healthier profiles.
Ana Barberá, Rosario Ortolá, Mercedes Sotos‐Prieto, Fernando Rodríguez‐Artalejo, Andrés Moya, Susana Ruiz‐Ruiz   +5 more
wiley   +1 more source

Iron-deplete diet enhances Caenorhabditis elegans lifespan via oxidative stress response pathways. [PDF]

EMBO J
Das P, Ravi, Singh J.
europepmc   +1 more source

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin‐Converting Enzyme Inhibitor Lisinopril

Aging Cell, Volume 25, Issue 2, February 2026.
Assessment of oxygen consumption rates in young, middle‐aged, and old flies from the Drosophila B lines and long‐lived O lines revealed a significant increase in metabolic rate with aging only in B flies. Lisinopril prevented the age‐related rise in metabolic rate in B female flies.
Denise Vecchié, Robert R. H. Anholt, Trudy F. C. Mackay, Maria De Luca   +3 more
wiley   +1 more source

Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age. [PDF]

Nat Immunol
Wang Y, Li R, Tong R, Chen T, Sun M, Luo L, Li Z, Chen Y, Zhao Y, Zhang C, Wei L, Lin W, Chen H, Qian K, Chen AF, Liu J, Chen L, Li B, Wang F, Wang L, Su B, Pu J.   +21 more
europepmc   +1 more source

MSC‐Derived Exosomal lnc‐AGT‐3: A Novel Anti‐Angiogenic Target in Age‐Related Macular Degeneration Through p53 Signaling Pathway

Aging Cell, Volume 25, Issue 2, February 2026.
MSC‐derived exosomes deliver lnc‐AGT‐3 to vascular endothelial cells, where it binds hnRNP K in the nucleus. This interaction inhibits p53 ubiquitination, enhancing p53 stabilization and transcriptional activation of anti‐angiogenic targets TSP1. Consequently, p53‐mediated signaling is potentiated, effectively suppressing choroidal neovascularization ...
Lingjie Kong, Xiaoyan Han, Siyi Qi, Duo Li, Jingyue Zhang, Linyu Zhang, Shujie Zhang, Qin Jiang, Biao Yan, Chen Zhao   +9 more
wiley   +1 more source

Rapamycin Reverses the Hepatic Response to Diet‐Induced Metabolic Stress That Is Amplified by Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Aging exacerbates high‐fat diet (HFD) induced hepatic steatosis, and transcriptional dysregulation of pathways including inflammation, immune, and metabolic regulation in mouse liver and hepatocytes. The addition of rapamycin to HFD reversed most HFD‐driven gene‐expression changes in old mice, including those linked to metabolic dysfunction and ...
Aaron Havas, Adarsh Rajesh, Xue Lei, Jessica Proulx, Karl N. Miller, Adam Field, Andrew Davis, Marcos Garcia Teneche, Armin Gandhi, Jin Lee, Gen‐Sheng Feng, Peter D. Adams   +11 more
wiley   +1 more source

Neutrophils drive vascular occlusion, tumour necrosis and metastasis. [PDF]

Nature
Adrover JM, Han X, Sun L, Fujii T, Sivetz N, Daßler-Plenker J, Evans C, Peters J, He XY, Cannon CD, Ho WJ, Raptis G, Powers RS, Egeblad M.   +13 more
europepmc   +1 more source

Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth‐Associated Proteins

Aging Cell, Volume 25, Issue 2, February 2026.
We characterized the plasma proteomic profiles of centenarians from the SWISS100 cohort, identifying 583 differentially expressed proteins compared to younger and geriatric groups. Cross‐validation with the independent datasets NECS and the TAME consortium confirmed a robust aging signature, while fractional polynomial regressions revealed a specific ...
Flavien Delhaes, Justine Falciola, Adar Hoffman, Stéphanie Carnesecchi, Stefano Cavalli, Armin von Gunten, Daniela S. Jopp, François R. Herrmann, Karl‐Heinz Krause   +8 more
wiley   +1 more source

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit. [PDF]

Nature
Pokatayev V, Jaiswal A, Shih AR, Segerstolpe Å, Li B, Creasey EA, Zhao Y, Lin C, Murphy S, Chou CH, Graham DB, Xavier RJ.   +11 more
europepmc   +1 more source

Certain Extended Mock Theta Functions and Generalised Basic Hypergeometric Transformations.

MATHEMATICA SCANDINAVICA, 1970
openaire   +2 more sources