Results 71 to 80 of about 362,737 (245)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
New exact solutions of cubic nonlinear schrödinger equation by using extended trial equation method
, 2020 Bu çalışmada, kısmi türevli diferansiyel denklemlerin tam çözümlerinin elde edilmesine olanak sağlayan genişletilmiş deneme denklem yöntemi incelenmiştir. Önerilen bu yöntem kübik lineer olmayan Schrödinger denklemine uygulanmış ve farklı yeni tam çözümleri elde edilmiştir.
PANDIR, Yusuf, AĞIR, Tural
openaire +2 more sources
Backflow Correlations for the Electron Gas and Metallic Hydrogen
, 2003 We justify and evaluate backflow-threebody wavefunctions for a two component system of electrons and protons. Based on the generalized Feynman-Kacs formula, many-body perturbation theory, and band structure calculations, we analyze the use and the ...
Ceperley, D. M. +3 more
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
, 2004 The effect of an in-plane magnetic field upon open quasi-two-dimensional electron and hole systems is investigated in terms of the carrier ground-state spectrum.
I. M. Lifshits +5 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
The Effect of Substituting Wheat Straw with Sugarcane Bagasse on Nutrient Digestibility, Blood Parameters, and Performance in Fattening Zandi Lambs [PDF]
پژوهشهای تولیدات دامیExtended Abstract Background: The production of lignocellulosic materials from agricultural and industrial activities is substantial worldwide, representing the most abundant renewable energy source on earth.
Mohammad Doosti Fard +1 more
doaj
Transition metal oxides using quantum Monte Carlo
, 2007 The transition metal-oxygen bond appears prominently throughout chemistry and solid-state physics. Many materials, from biomolecules to ferroelectrics to the components of supernova remnants contain this bond in some form.
+11 more
core +1 more source