Results 161 to 170 of about 590,994 (248)

A single-vesicle fluorescence microscopy platform to quantify phospholipid scrambling. [PDF]

Nat Struct Mol Biol
Veit S, Dearden GI, Menon KM, Noor F, Menon I, Morizumi T, Ernst OP, Menon AK, Pomorski TG.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Four ppm measurement of the antihydrogen ground-state hyperfine splitting. [PDF]

Nature
Akbari R, de Araujo Azevedo LO, Baker CJ, Bertsche W, Bhatt NM, Bonomi G, Capra A, Carli I, L Cesar C, Charlton M, Cridland Mathad A, Del Vincio A, Duque Quiceno D, Eriksson S, Evans A, Fajans J, Friesen T, Fujiwara MC, Golino LM, Gomes Gonçalves MB, Hangst JS, Hayden ME, Heidari P, Hodgkinson D, Isaac CA, Jones SA, Jonsell S, Madsen N, Marshall VR, McKenna JTK, Momose T, Nauta J, Oliveira AN, Powell A, Rasmussen CØ, Robertson-Brown T, Robicheaux F, Sacramento RL, Sarid E, Schoonwater J, Silveira DM, Singh J, Smith G, So C, Stracka S, Suh J, Swadling AG, Tharp TD, Thompson KA, Thompson RI, Thorpe-Woods E, Uribe Jimenez AJ, Urioni M, van de Werf DP, Wilson SG, Woosaree P, Wurtele JS, ALPHA Collaboration.   +57 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Liquid biopsy for the diagnosis of EBV-positive Burkitt's lymphoma in endemic areas. [PDF]

Nat Med
Chamba C, Christopher H, Josephat E, Sseruyange J, Ayitewala A, Howard K, Dreau H, Burns A, Legason I, Otim I, Mapendo P, Mnango L, Ngaiza A, Mremi A, Elias E, Achola C, Mawalla W, Shungu R, Mkwizu E, Chirande L, Mwamtemi H, Mahawi S, Sandi G, Kashaigili HJ, Gerlevik S, Ntemi PS, Magorosa E, Mbwambo D, Tungu M, Ogwang M, Chiwanga F, Mbulaiteye SM, El Mouden C, Balandya E, Cutts A, Morrell L, Vavoulis D, Schuh A.   +37 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A prototype differential atom interferometer for fundamental physics. [PDF]

Nature
Baynham CFA, Hobson R, Buchmüller O, Evans D, Hawkins L, Iannizzotto Venezze L, Josset A, Lee D, Pasatembou E, Sauer BE, Tarbutt MR, Walker T, Ennis O, Chauhan U, Brzakalik A, Dey S, Hedges S, Stray B, Langlois M, Bongs K, Hird T, Lellouch S, Holynski M, Bostwick B, Chen J, Eyler Z, Gibson V, Harte TL, Hsu CC, Karzazi M, Lu C, Millward B, Mitchell J, Mouelle N, Panchumarthi B, Scheper J, Schneider U, Su X, Tang Y, Tkalčec K, Zeuner M, Zhang S, Zhi Y, Badurina L, Beniwal A, Blas D, Carlton J, Ellis J, McCabe C, Parish G, Govardhan DP, Vaskonen V, Bowcock T, Bridges K, Carroll A, Coleman J, Elertas G, Hindley S, Metelko C, Throssell H, Tinsley JN, Bentine E, Booth M, Bortoletto D, Callaghan N, Foot C, Gómez-Monedero C, Hughes K, James A, Leese T, Lowe A, March-Russell J, Sander J, Schelfhout J, Shipsey I, Weatherill D, Wood D, Balashov SN, Bason MG, Hussain K, Labiad H, Majewski P, Marchant AL, Newbold D, Pan Z, Tam Z, Thornton TC, Valenzuela T, van der Grinten MGD, Wilmut I, Clarke K, Vick A, AION Collaboration.   +92 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The local mechanostructural properties of protein cargoes regulate nucleocytoplasmic transport. [PDF]

Nat Phys
Tapia-Rojo R, Milmoe N, Paracuellos P, Lally B, Escalona-López C, Masino L, Gehlen J, Walker J, Garcia-Manyes S.   +8 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source