Results 61 to 70 of about 590,994 (248)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Computer Modeling in Engineering & Sciences, 2011 We present a two phase flow conceptual model, the corresponding simulator (2pMINC) and a workflow for large-scale fractured reservoirs, based on a continuum fracture approach which uses the multiple interacting continua (MINC) method complemented with an improved upscaling technique.
A.B. Tatomir +3 more
openaire +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A numerical well model considering capillary end effect for the low-permeability gas reservoir
Oil & Gas Science and Technology, 2019 In the recovery of low permeability reservoir, the capillary pressure has an important effect, which may reduce gas production. Due to the capillary end effect, there are two flow patterns in the vicinity of the production well: both water and gas phases
Yao Yu-Min +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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iScienceSummary: An extended lithium-ion battery model is proposed, which simplifies the solid-liquid diffusion process compared with the full-order pseudo two-dimensional (P2D) model, in order to reduce computational complexity and enhance modeling speed.
Wei He +6 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
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Open PhysicsIn this article, the phase portraits, chaotic patterns, and traveling wave solutions of the conformable extended Korteweg–de-Vries (KdV) model are investigated.
Liu Chunyan
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A Phase-Offset Estimation Method for InSAR DEM Generation Based on Phase-Offset Functions
Remote Sensing, 2012 This paper presents a novel method for estimating the absolute phase offset in interferometric synthetic aperture radar (SAR) measurements for digital elevation model (DEM) generation. The method is based on “phase-offset functions (POF),” relating phase
João Roberto Moreira +3 more
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