Results 151 to 160 of about 1,140,794 (311)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Extending learning opportunities: a framework for self-evaluation in study support [PDF]
, 2009 The Extending Learning Opportunities (ELO) framework for self-evaluation in study support is a tool for quality assurance of the learning opportunities for children and young people outside of normal lesson time.
Moore, Joanne +4 more
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Extending learning opportunities: a framework for self-evaluation in study support [PDF]
, 2011 The Extending Learning Opportunities (ELO) framework for selfevaluation in study support is a tool to use when quality assuring learning opportunities for children and young people outside of normal lesson time. This framework is a revised edition of the
Moore, Joanne +4 more
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Preventing Chronic Disease, 2005 With this issue, Preventing Chronic Disease (PCD) begins its second year of publication. The expertise and enthusiasm of our authors, editors, reviewers, and board members enabled PCD to provide our readers with a unique view of public health and chronic
Lynne S. Wilcox, MD, MPH
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Advances in database technology - EDBT 2014: 17th International Conference on Extending Database Technology, Athens, Greece, March 24 - 28, 2014 ; proceedings [PDF]
, 2014 International Conference on Extending Database Technology ; 17. 2014 Athens
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source