Results 121 to 130 of about 951,346 (275)

Structuring of specification modules (extended)

open access: yesComput. Sci. J. Moldova, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Extending irreducible modules

open access: yesJournal of Algebra, 1981
An important part of Clifford’s theory does not work properly for arbitrary fields R. To see why, we must recall the main steps of this theory. We are interested in extensions to RH-modules of a fixed H-invariant irreducible RN-module a, where N is a normal subgroup of a finite group H. We first pass to the factor algebra ‘u = RH/3 modulo the ideal 3 =
openaire   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

基于AutoCAD的CHC型少齿差减速器参数化CAD系统

open access: yesJixie chuandong, 2012
A CAD system of CHC type reducer with few teeth difference is developed in Visual Basic 6.0 integrated programming environment.Two modules,calculating for design and parametric drawing are included in the system,which are communicated effectively by ...
陈满意, 黄忠敏, 石永科
doaj  

Data-driven and LCA-based Framework for environmental and circular assessment of Modular Curtain Walls

open access: yesJournal of Facade Design and Engineering
To assist the sustainable development of the building sector, designers require tools illustrating the most viable design options. This paper, starting by presenting the opportunities and limitations of the Life Cycle Assessment (LCA) methodology and ...
Luca Morganti   +7 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Projection invariant t-baer and related modules

open access: yes
We study the concepts of projection invariant t-extending modules and projection invariant t-Baer modules, which are generalized to the notions of π-extending and t-Baer modules, respectively.
Kara, Yeliz
core   +1 more source

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