Results 91 to 100 of about 917,527 (268)
BMC Genomics, 2008 Background Microarrays have the capacity to measure the expressions of thousands of genes in parallel over many experimental samples. The unsupervised classification technique of bicluster analysis has been employed previously to uncover gene expression ...
Cunningham Pádraig, Bryan Kenneth
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Pathological modules over tame rings [PDF]
, 1976 Brenner S, Ringel CM. Pathological modules over tame rings. Journal of the London Mathematical Society.
Ringel, Claus Michael, Brenner, Sheila
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Journal of Translational MedicineBackground Cancer originates from dysregulated cell proliferation driven by driver gene mutations. Despite numerous algorithms developed to identify genomic mutational signatures, they often suffer from high computational complexity and limited clinical ...
Xiangmei Li +8 more
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Distributed Application Extensions and Obsolescence as Risk Generating Factors [PDF]
Informatică economică, 2012 Extending distributed IT&C applications raises risks associated to integrating new modules in already existing functional areas, influencing performance and data relevancy.
Catalin Alexandru TĂNASIE
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Energies, 2019 The growing complexity and the many challenges related to fast-changing and highly de-carbonised electricity systems require reliable and robust open source energy modelling frameworks. Their reliability may be tested on a series of well-posed benchmarks
Francesco Gardumi +3 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Functional predictability of universal gene circuits in diverse microbial hosts
Quantitative BiologyAlthough the principles of synthetic biology were initially established in model bacteria, microbial producers, extremophiles and gut microbes have now emerged as valuable prokaryotic chassis for biological engineering.
Chenrui Qin +7 more
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Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source