Results 81 to 90 of about 917,527 (268)
Dynamic rendering of the heterogeneous cell response to anticancer treatments. [PDF]
PLoS Computational Biology, 2013 The antiproliferative response to anticancer treatment is the result of concurrent responses in all cell cycle phases, extending over several cell generations, whose complexity is not captured by current methods.
Francesca Falcetta +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Assessing the Environmental Benefits of Extending the Service Lifetime of Solar Photovoltaic Modules
Global ChallengesRequiring no fuel for generation and negligible material/energy for operation and maintenance, photovoltaic (PV) systems have environmental impacts mostly due to the production of modules and the commissioning of power plants. Thus, extending the service
Ahmed Burak Paç, Abdulkerim Gok
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Energies, 2017 The combination of lithium ion battery (LIB) and organic (polymer) solar cells is expected to deliver versatile self-rechargeable portable energy sources, but less attention has been paid to the charging characteristics of LIB-using polymer solar cells ...
Myeonghun Song +9 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
On Extending Scott Modules [PDF]
, 2017 We study a variety of questions related to the Scott modules S(G,Q) associated to a finite group G, where Q denotes a p-subgroup of G for a given prime p. The main concept we study is that of a p-extendible group, which we define to be a group in which the dimension of S(G,Q) is minimal for all p-subgroups Q of G. We study those
Gullon, Alec, Mazza, Nadia
openaire +2 more sources
Intuitionistic fuzzy group algebra [PDF]
Notes on IFSThis paper introduces the concept of an intuitionistic fuzzy group algebra associated with a finite group G and an intuitionistic fuzzy group A on G.
Poonam Kumar Sharma
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source