Results 131 to 140 of about 8,725 (216)

Real‐world effectiveness and safety of acalabrutinib in chronic lymphocytic leukaemia: Multicentre experience

open access: yesBritish Journal of Haematology, EarlyView.
Summary Chronic lymphocytic leukaemia (CLL) primarily affects elderly patients with comorbidities, yet real‐world data on acalabrutinib, a second‐generation Bruton's Tyrosine Kinase (BTK) inhibitor, remain limited outside clinical trials, particularly in Italy.
Andrea Duminuco   +21 more
wiley   +1 more source

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

open access: yesBritish Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco   +8 more
wiley   +1 more source

International Delphi consensus on feminising genital surgery in assigned‐male‐at‐birth individuals

open access: yesBJU International, EarlyView.
Objective To achieve an international expert consensus among surgeons on the indications, contraindications, and perioperative management of feminising genital surgery (FGS) for assigned‐male‐at‐birth (AMAB) individuals, using a Delphi process. Methods A two‐round on‐line Delphi survey (May–July 2025) followed by a final consensus meeting (September ...
Marta Pezzoli   +30 more
wiley   +1 more source

Safe to Spare? Predictors of Oncological Safety for Nerve-Sparing Technique during Robot-Assisted Radical Prostatectomy in High-Risk Prostate Cancer. Insight from a High Volume Center with Centralized mpMRI Review. [PDF]

open access: yesInt Braz J Urol
Lambertini L   +20 more
europepmc   +1 more source

Molecular heterogeneity and prognostic biomarkers in primary meningeal melanocytic tumors

open access: yesBrain Pathology, EarlyView.
Integrated molecular profiling reveals biological heterogeneity among primary meningeal melanocytic tumors, identifying intermediate‐grade PMMT subgroups with distinct recurrence risk. Molecular alterations including SF3B1 mutations and chromosome 8q gains support prognostic stratification, while PRKAR1A alterations and chromosome 17/21q losses aid ...
Rosina Paterra   +6 more
wiley   +1 more source

Spectral Precision: The Added Value of Dual-Energy CT for Axillary Lymph Node Characterization in Breast Cancer. [PDF]

open access: yesCancers (Basel)
Guerrini S   +11 more
europepmc   +1 more source

Visual Cues for Logical Reasoning about Text Enhance Metacognitive Sensitivity

open access: yesComputer Graphics Forum, EarlyView.
Abstract An important part of critical thinking is analyzing the logical structure of inferences made in text, such as checking whether if–then rules appearing in legal regulations or scientific arguments are applied correctly. Metacognitive sensitivity, defined as feeling confident about one's correct answers and uncertain about incorrect ones, is an ...
A. Schlieder, J. Rummel, F. Sadlo
wiley   +1 more source

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