Results 141 to 150 of about 6,125,058 (320)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
A legitimação dos direitos dos animais não-humanos e a conscientização da sociedade contemporânea
Revista Interdisciplinar de Direito, 2014 The article aims to collate and highlight the need for awareness of contemporary society to create a system for the protection of non-human animals, since these are subjects of a life.
Ronald Luiz do Valle Andrade
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Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
First Evidence of Axial Shape Asymmetry and Configuration Coexistence in $^{74}$Zn: Suggestion for a Northern Extension of the $N=40$ Island of Inversion [PDF]
, 2023 M. Rocchini +43 more
openalex +1 more source
, 1983 The most general model used to describe conflict situations is the extensive form model, which specifies in detail the dynamic evolution of each situation and thus provides an exact description of ‘who knows what when’ and ‘what is the consequence of which’.
openaire +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
The evaluation of a participatory extension programme focused on climate friendly farming
, 2020 Jorie Knook +3 more
openalex +2 more sources
SVR-EEMD: An Improved EEMD Method Based on Support Vector Regression Extension in PPG Signal Denoising [PDF]
, 2019 Guangda Liu +5 more
openalex +1 more source