Results 141 to 150 of about 1,403,434 (266)

Full Issue, Volume 2, Number 2

open access: yesJournal of Human Sciences and Extension, 2014
Journal of Human Sciences and Extension
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Full Issue, Volume 2, Number 1

open access: yesJournal of Human Sciences and Extension, 2014
Journal of Human Science and Extension
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Full Issue, Volume 5, Number 1

open access: yesJournal of Human Sciences and Extension, 2017
Journal of Human Sciences and Extension
doaj  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Full Issue, Volume 3, Number 3

open access: yesJournal of Human Sciences and Extension, 2015
Journal of Human Sciences and Extension
doaj  

Home - About - Disclaimer - Privacy