Results 91 to 100 of about 58,470 (264)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Using food distributors in the Northwest : a guide for new manufacturers

Creating a new food product is exciting; selling it is challenging. The thrill of creating a new product often subsides once the task of developing sales becomes the priority.
Johnson, Aaron J., Beaman, Jill A., Oregon State University. Extension Service   +2 more
core  

Advances in Sustainable and Wearable Textile Based Soft Robotics

Advanced Functional Materials, EarlyView.
This Review examines advances in wearable textile‐based soft robotics, focusing on sustainable materials, integrated sensing, and scalable actuation. It discusses manufacturing and system integration across healthcare, assistive robotics, prosthetics, and human–machine interfaces, and highlights key challenges in circular design, including life‐cycle ...
Zahir Abbas, Marzia Dulal, Sophia K. Novoselov, Victoria K. Novoselov, Kostya S. Novoselov, Shaila Afroj, Nazmul Karim   +6 more
wiley   +1 more source

Conformal Metallosaccharide Hybrid Films for Protecting Wood Surfaces From Environmental Damage

Advanced Functional Materials, EarlyView.
Ti‐ribose hybrid films fabricated by molecular layer deposition form a conformal and uniform coating on wood surfaces, which provides water repellence, dimensional stability, and resistance to acidic and alkaline environments, while preserving the natural appearance.
Wenwen Wang, Aranzazu Sierra Fernandez, Gabriele Botta, Evgenii Modin, Iva Šarić Janković, Shidong Ji, Junli Liu, Mato Knez   +7 more
wiley   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

User contributions and public extension delivery modes: implications for financial sustainability of extension in South Africa

, 2014
Extension channels form the bridge that extension agents use to communicate messages to recipients. The high recurrent costs faced by the public extension service constraint the number of visits farmers receive.
Afful, D. B, Lategan, F. S
core  

Challenges to Effective Use of Information Commnicatio Technologies (ICTs) in the Delivery of Agricultural Extension Service

, 2007
The promise of Information Communication Technology (ICT) in agricultural extension is that it can energize the collection processing and transmission of data, resulting in faster extension of quality information to more farmers a bottom-up ...
N Ozor
core   +2 more sources

Packed Hydrogel Microfibers as Scaffolds Supporting Dynamic Cellular Behavior and Biomaterial Inks in 3D Printing

Advanced Healthcare Materials, EarlyView.
Packed hydrogel microfiber (PHM) materials consist of flexible and high aspect ratio hydrogel components that, as a bulk material, are simultaneously mechanically robust and dynamic. Cells cultured in or on PHM scaffolds can be influenced by topographical cues or interact with a dynamic environment that permits cell spreading and multicellular ...
M. Gregory Grewal, Remington M. Martinez, Georgia T. Helein, Montserrath G. Ibarra Rivera, Rodolfo Martinez Jr., Jenna L. Sumey, Steven R. Caliari, Christopher B. Highley   +7 more
wiley   +1 more source

"Participation and linkages for improved extension delivery" – the role of the extension worker

, 2006
Sustainable agricultural development is only possible if there is participation and clear linkages between the role players that will ensure improved extension (service) delivery.
Terblanché, SE
core   +1 more source

Learning Capabilities of Extension Professionals in Using Social media Platforms for Service Delivery in Southeast, Nigeria

Journal of Agricultural Extension
The study ascertained extension professionals learning capabilities in using social media platform for service delivery in southeast, Nigeria. The population for the study comprised one hundred and twenty-seven extension professionals (academic staff of
Charles Ekene Udoye, Michael Chukwuneke Madukwe   +1 more
doaj