Results 71 to 80 of about 78,827 (231)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Use of Computer and Internet in Agricultural Extension as Perceived by Extension Workers [PDF]

International Journal of Agricultural Management and Development, 2014
The purpose of this study was to determine computer and Internet use in agricultural extension by Extension Workers (EWs). This study used a descriptive-correlational design.
Gholamreza Pezeshki Rad, Zahra Haji Hashemi, Mohhamad Chizari   +2 more
doaj  

HUBUNGAN KARAKTERISTIK, MOTIVASI DAN KOMPETENSI TERHADAP PRODUKTIVITAS KERJA PENYULUH PERTANIAN DI KOTA BENGKULUHUBUNGAN KARAKTERISTIK, MOTIVASI DAN KOMPETENSI TERHADAP PRODUKTIVITAS KERJA PENYULUH PERTANIAN DI KOTA BENGKULU

Jurnal Agrisep, 2013
The objective of this research is to analyze the correlation of the agricultural agents’ characteristics, motivation and competence to their work productivity. This research was conducted in February through April 2013 and used census methods. The study
M. Ali Hanafiah, Witman Rasyid, Agus Purwoko   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Proficiency for Digital Extension Service Delivery among Public Agricultural Extension Personnel in Imo State, Nigeria

Journal of Agricultural Extension
The study examined proficiency for digital extension services delivery among public extension personnel in Imo State, Nigeria. A sample of 120 extension personnel selected from the Imo State ADP using multistage sampling procedure participated in the ...
Polycarp Chika Umunakwe, Michael Chukwuneke Madukwe , Francis Chudi Anaeto, Rachel Nkeonyere Nwakwasi, Ogbonnaya Okoro Aja   +4 more
doaj   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Analysis of Training Needs of Extension Agents on Climate

Journal of Agricultural Extension, 2012
The study specifically examined tasks performed by extension agents in the EKSADP as related to climate change and the task areas in which they needed further training.
R S Adisa, K S Balogun
doaj   +4 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source