Results 201 to 210 of about 175,539 (259)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Complex transsphincteric ano-rectal fistula with circumferential perirectal abscess and periprostatic extension: the added value of contrast-enhanced pelvic MRI. [PDF]

BJR Case Rep
Nguyen CP, Huynh QH.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Distance-based assessment of spatial artifact extension in the prostate from fiducial markers in diffusion-weighted magnetic resonance imaging. [PDF]

J Appl Clin Med Phys
Coskun M, Brynolfsson P, Gustafsson CJ, Gunnlaugsson A, Olsson LE.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Extended Grammar of Systematized Nomenclature of Medicine - Clinical Terms for Semantic Representation of Clinical Data: Methodological Study. [PDF]

J Med Internet Res
Gaudet-Blavignac C, Ehrsam J, Baumann M, Bensahla A, Mattei M, Zheng Y, Lovis C.   +6 more
europepmc   +1 more source

Three-Unit Prosthesis Supported by a Single Implant With Two Cantilever Extensions in the Posterior Region (T-Bridge): Case Report With a 2-Year Follow-Up. [PDF]

Clin Case Rep
Silva JR, Leles CR, Moura-Neto LO, Brägger U, Schimmel M, Fonseca M.   +5 more
europepmc   +1 more source

Bivalent impact of social networks on overarming: Insights on the alignment between social and individual interests. [PDF]

Sci Adv
Fu F, Herron M, Rockmore D.
europepmc   +1 more source

What AI Cannot Teach: An Epistemological Reconceptualisation of the Nurse Educator Role Based on an Analysis of Carper's Ways of Knowing. [PDF]

Nurs Inq
Sezer E.
europepmc   +1 more source