Results 161 to 170 of about 4,429,440 (301)

Safe definitive surgery in unstable pelvic ring injuries - a retrospective cohort study. [PDF]

Eur J Orthop Surg Traumatol
Bästlein CV, Klingebiel FK, Hübner CT, Kalbas Y, Klee O, Pape HC, Pfeifer R.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Artificial intelligence for evaluation of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer. [PDF]

PLOS Digit Health
Huang H, Feng L, Zhong ME, Ye H, Li Z, Yao S, Ye Y, Liu Y, Zhao M, Xu W, Yan L, Xie C, Liang C, Liu Z, Tong T, Cui Y, Fan XJ, Zhao K.   +17 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

The Shifting Composition of External Liabilities [PDF]

What determines the composition of external liabilities, both across countries and over time? More specifically, which countries account for the massive increase in equity-like liabilities (foreign direct investment and portfolio equity), especially ...
Gian Maria Milesi-Ferretti, André Faria, Philip R. Lane, Paolo Mauro   +3 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Identification and validation of a chronic kidney disease prediction model after radical nephrectomy: a multicenter cohort retrospective study. [PDF]

Ann Med
Wang X, Zhang T, Wang J, Yan Y, Wang H, Song K, Yu Y, Zhang Z, Zou B, Yao C, Zheng J, Liu J, Liu H, Zhang X, Guan C, Xu L, Zhang N, Jiao W.   +17 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Artificial Intelligence for the Diagnosis of Transthyretin Amyloid Cardiomyopathy: A Systematic Review of Machine Learning Application. [PDF]

Cardiol Res Pract
Jamileh E, Elmewafy AT, Qadeer MA, Zulfiqar Z, Kang K, Hosseini K, Antoun I.   +6 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source