Results 131 to 140 of about 525,919 (347)

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

open access: yesAdvanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia   +13 more
wiley   +1 more source

Excitation of nonlinear ion acoustic waves in CH plasmas

open access: yes, 2016
Excitation of nonlinear ion acoustic wave (IAW) by an external electric field is demonstrated by Vlasov simulation. The frequency calculated by the dispersion relation with no damping is verified much closer to the resonance frequency of the small ...
Feng, Q. S.   +5 more
core   +2 more sources

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

open access: yesAdvanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu   +20 more
wiley   +1 more source

Multimodal Layer‐Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes

open access: yesAdvanced Science, EarlyView.
The study introduces a flexible microfluidic axialtrode that integrates optical, electrical, and chemical modalities within a single polymer fiber. By redistributing electrodes and fluidic channels along the fiber axis via angled cleaving, it enables simultaneous optogenetic stimulation, electrophysiological recording, and drug delivery across brain ...
Kunyang Sui   +8 more
wiley   +1 more source

Cholesterol granuloma presenting as a mass obstructing the external ear canal [PDF]

open access: hybrid, 2010
Vasilios Nikolaidis   +3 more
openalex   +1 more source

Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy

open access: yesAdvanced Science, EarlyView.
An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo   +13 more
wiley   +1 more source

Surgical concepts for reconstruction of the auricle [PDF]

open access: yes, 1986
We compiled and evaluated the world literature on auricular reconstruction, for a total of over 400 publications, more than 200 authors, and over 3,300 reported cases. We found that partial reconstructions were already performed as early as 600 BC; total
Berghaus, Alexander, Toplak, F.
core  

Stationary plasmon-soliton waves in metal-dielectric nonlinear planar structures: modeling and properties

open access: yes, 2013
We present three complementary methods to study stationary nonlinear solutions in one-dimensional nonlinear metal-dielectric structures. Two of them use an approximate treatment of the Kerr type nonlinear term taking into account only the leading ...
Kartashov, Yaroslav   +2 more
core   +3 more sources

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

open access: yesAdvanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li   +7 more
wiley   +1 more source

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