Results 81 to 90 of about 2,875,232 (333)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

A New Type of External Fixation

Engineering Transactions, 2015
The paper presents some problems related to external osteosynthesis. Design of the new generation of external fixators should use modelling, computer simulation and clinical postulates.
D. Jasińska-Choromańska, J. Deszczyński   +1 more
doaj   +1 more source

Photoactive TiO2 antibacterial coating on surgical external fixation pins for clinical application

, 2015
Guillaume Villatte,1,2 Christophe Massard,1 Stéphane Descamps,1,2 Yves Sibaud,1 Christiane Forestier,3 Komla-Oscar Awitor1 1Laboratory C-Biosenss EA 4676, Clermont-Ferrand University, Université d’Auvergne, Clermont-Ferrand, France ...
Villatte G, Sibaud Y, Forestier C, Awitor KO, Massard C, Descamps S   +5 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Comparison of internal and external fixation of distal radius fractures

Acta Orthopaedica, 2013
Background and purpose There is no consensus on the difference in effects of internal fixation (IF) and external fixation (EF) on outcomes for the treatment of distal radius fractures. We performed a meta-analysis of randomized clinical studies.
Xuetao Xie, Xiaoxing Xie, Hui Qin, Longxiang Shen, Changqing Zhang   +4 more
semanticscholar   +1 more source

External fixation for comminuted phalangeal fractures: A biomechanical cadaver study

, 1996
The mechanical rigidity obtained by external fixation in a comminuted phalangeal fracture model was assessed and the results compared with two other types of internal fixation commonly used (lateral plate and crossed Kirschner wires) in a biomechanical ...
Fitoussi, F, Chow, SP, Ip, WY
core   +1 more source

Conversion of external fixation to internal fixation in a non-acute, reconstructive setting : a case series [PDF]

, 2013
The aim of the study is to determine the outcomes in patients who underwent conversion from an external fixator to an internal fixation device. This is a retrospective review of 18 patients (24 limbs) who underwent conversion from external to ...
P. de Lange, Birkholtz, Franz Friedrich, Snyckers, Christian Hugo, Monni, T., De Lange, P., F. F. Birkholtz, C. H. Snyckers, T. Monni   +7 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Finite element analysis of the stability of tibiofibular fractures treated with various combinations of external fixators

BMC Musculoskeletal Disorders
Background External fixators have been extensively applied in the treatment of open tibiofibular fractures and have yielded positive outcomes. The stability of an external fixator primarily hinges on its structure.
Xubiao Ye, Jinling Luo, Pu Chen, Xiaohua Wei, Shifeng Liu   +4 more
doaj   +1 more source