Results 171 to 180 of about 29,546 (225)

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 4646-4662, August 2026.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh   +5 more
wiley   +1 more source

Human Pharmacokinetic Prediction of Antibody‐Drug Conjugates Using Human FcRn Transgenic Mice

open access: yesClinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) have progressed significantly in recent years, particularly in the oncology field. However, predicting human pharmacokinetics (PK) of ADCs in the early stages of drug development remains challenging. Human neonatal Fc receptor (FcRn) transgenic mice have been established as a reliable pre‐clinical PK model for ...
Keitaro Nakagawa, Kenta Haraya
wiley   +1 more source

Acute Myocarditis: From Pathophysiology to Risk‐Stratified Management—A Clinical Review

open access: yesEuropean Journal of Clinical Investigation, Volume 56, Issue 8, August 2026.
Stepwise approach to patients with suspected acute myocarditis, integrating the 2024 American College of Cardiology (ACC) four‐stage classification (Stages A–D) and the 2025 European Society of Cardiology (ESC) inflammatory myopericardial syndrome (IMPS) framework. Step 1 (Initial Assessment): clinical presentation, first‐line investigations (ECG, high‐
Michele Golino   +9 more
wiley   +1 more source

Effect of aging on healing of mandibular tooth extraction socket in a rat model

open access: yesEuropean Journal of Oral Sciences, Volume 134, Issue 4, August 2026.
Abstract This study evaluated the effect of aging on bone regeneration in mandibular extraction sockets. Male Sprague–Dawley rats were divided into three age groups: 2‐month‐old (2 M, n = 6), 10‐month‐old (10 M, n = 6), and 18‐month‐old (18 M, n = 5). Two weeks post‐extraction, comprehensive analyses were performed using micro‐computed tomography (µ‐CT)
Kyung Su Shin   +7 more
wiley   +1 more source

Primary cardiac T‐cell rich large B‐cell lymphoma causing aortic stenosis with metastasis in a Warmblood

open access: yesEquine Veterinary Education, Volume 38, Issue 8, Page e488-e495, August 2026.
Summary An 18‐year‐old Warmblood mare was presented to the Royal Veterinary College Equine Referral Hospital for investigation of progressive periocular and facial swelling, weight loss and tachycardia. Physical examination additionally identified bilateral pansystolic (grade 5/6 basilar left‐sided, 2/6 right‐sided), cardiac murmurs, submandibular ...
S. E. Talbot   +4 more
wiley   +1 more source

Technical note on an ovine model to study biomedical implants intended for maxillofacial reconstruction

open access: yesVeterinary Surgery, Volume 55, Issue 6, Page 1152-1164, August 2026.
Abstract Objective To describe a repeated‐measures model permitting evaluation of up to four implants intended for maxillofacial applications in sheep. Animals Two‐year‐old Merino wethers (n = 5). Methods A retromandibular subparotid approach was developed through anatomical study of atlases, predissected models and cadaveric experiments.
Reza Sanaei   +7 more
wiley   +1 more source

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