Results 71 to 80 of about 322,279 (243)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Electrostatic tuning of mechanical and microwave resonances in 3D superconducting radio frequency cavities

AIP Advances, 2018
We implement a non-contact, external method of simultaneously fine-tuning a mechanical resonator and a superconducting radio frequency (SRF) cavity using a capacitor formed between a silicon nitride membrane and a copper electrode at cryogenic ...
Jacob M. Pate, Luis A. Martinez, Johnathon J. Thompson, Raymond Y. Chiao, Jay E. Sharping   +4 more
doaj   +1 more source

Optical coherence tomography and autofluorescence findings in chronic phototoxic maculopathy secondary to snow-reflected solar radiation

Indian Journal of Ophthalmology, 2015
A professional mountain trekker presented with gradual, moderate visual decline in one eye. The subnormal vision could not be explained by the examination of anterior and posterior segment of either eye, which was unremarkable.
Dhananjay Shukla
doaj   +1 more source

Electron microscopy study of the central retinal fovea in Pied flycatcher: evidence of a mechanism of light energy transmission through the retina

Heliyon, 2020
We present unique ultrastructural data on avian retinal cells. Presently and earlier (Zueva et al., 2016) we explored distribution of intermediate filaments (IFs) in retinal cells of the Pied flycatcher (Ficedula hypoleuca, Passeriformes, Aves) in the ...
Lidia Zueva, Tatiana Golubeva, Elena Korneeva, Oscar Resto, Mikhail Inyushin, Igor Khmelinskii, Vladimir Makarov   +6 more
doaj   +1 more source

The effects of water and microstructure on the performance of polymer electrolyte fuel cells [PDF]

, 2006
n this paper, we present a comprehensive non-isothermal, one-dimensional model of the cathode side of a Polymer Electrolyte Fuel Cell. We explicitly include the catalyst layer, gas diffusion layer and the membrane.
A. Young, A.A. Shah, Aris, Berg, Bird, Broka, Cao, Carnes, Eikerling, Eikerling, G.-S. Kim, Ge, Guo, Guo, He, Hinatsu, Hsuen, J. Li, Jaouen, Ju, K. Promislow, Lampinen, Lin, Lister, Liu, Mathias, Mazumder, Mazumder, Mazumder, Middelman, Mizuhata, Motupally, Nam, Natarajan, Ogumi, Pasaogullari, Perry, S. Ye, Siegel, Siegel, Song, Springer, Sukkee Um, Sun, Thapman, Uchida, Uchida, Van Nguyen, W. Gervais, Wang, Wang, Wang, Wang, Weber, Weber, Weng, Weng, Williams, Yang, Yin   +59 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Rhinosporidiosis of the tarsal conjunctiva

Indian Journal of Ophthalmology, 2015
Rhinosporidiosis is a rare infection caused by Rhinosporidium seeberi, an organism classified in its own class, mesomycetozoea. It commonly affects mucus membranes namely the nasal mucosa, pharynx and the conjunctiva. We present the case of an 8-year-old
Akshay Gopinathan Nair, Mohammad Javed Ali, Swathi Kaliki, Milind N Naik   +3 more
doaj   +1 more source

Holographic QCD with Topologically Charged Domain-Wall/Membranes

, 2008
We study the thermodynamical phase structures of holographic QCD with nontrivial topologically charged domain-wall/membranes which are originally related to the multiple $\theta$-vacua in the large $N_c$ limit.
Lin, Feng-Li, Wu, Shang-Yu
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source