Results 41 to 50 of about 194,855 (260)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Open EngineeringDue to the disposal of different wastewater into the water bodies, the rate of surface water pollution is increasing. The virginia initiative plant (VIP), one of the most efficient and economical wastewater treatment systems, was assessed.
Kadhim Ayat Mahdi +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
Double nerve transfer with anterior shoulder release for restoration of shoulder abduction and external rotation in cases of obstetric brachial plexus palsy sequelae [PDF]
Al-Azhar International Medical JournalBackground: Persistent shoulder impairment is observed in 30% of cases with obstetric brachial plexus palsy, even after early management. Residual shoulder internal rotation contractures and limited abduction/external rotation necessitate reconstructive ...
Mahmoud Ragab +3 more
doaj +1 more source
The externally rotated leg: Anterior dislocation of the hip [PDF]
Emergency Medicine Journal, 1994 A case report of anterior dislocation of the hip presenting as a fractured neck of femur following a minor fall in an elderly patient.
D P, Jones, R N, Villar
openaire +2 more sources
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
Nerve Transfers for Brachial Plexus Injury: A Pathway to Functional Restoration
Journal of Orthopaedic Case ReportsIntroduction: The objective of the study is to evaluate the functional outcomes of nerve transfer procedures in adults with post-traumatic irreparable upper root brachial plexus injuries (BPIs).
Rachit Bhatnagar +4 more
doaj +1 more source