Results 51 to 60 of about 61,760 (287)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Integrated nursing of Traditional Chinese and western medicine for a patient undergoing thrombolytic therapy for acute mesenteric venous thrombosis (1例急性肠系膜静脉血栓患者溶栓后的中西医结合护理)

中西医结合护理, 2021
This paper summarized the nursing of integrated Traditional Chinese and western medicine for a patient undergoing thrombolytic therapy for acute mesenteric venous thrombosis.
TONG Fenfei (仝粉飞), ZHEN Wen (郑雯), ZHI Hui (智慧), LOU Jinjing (刘津京)   +3 more
doaj   +3 more sources

Targeting digestive system cancers with isoliquiritigenin: a comprehensive review of antitumor mechanisms

Frontiers in Pharmacology
Digestive system malignancies, including gastric, colorectal, and liver cancers, account for a substantial proportion of global cancer morbidity and mortality.
Zhichun Li, Ruohan Feng, Jinze Li, Jinglu Bai, Nuo Li, Zhenhua Cui, Zhenhua Cui, Xiaobin Zhang   +7 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

External application of traditional Chinese medicine in the treatment of bone cancer pain: a meta-analysis [PDF]

Supportive Care in Cancer, 2015
Bone cancer pain presents a clinical challenge with limitations of current treatments. Many patients seek additional therapies that may relieve pain. Many external applications of traditional Chinese medicines (EAs-TCMs) have been evaluated in clinical trials, but fewer are known about them outside of China. The objective of this study is to assess the
Xiangyong, Yan, Zhongsheng, Yan, Wenchao, Liu, Hui, Ding, Shuzhou, Qiao, Gang, Chen, XiaoHui, Wang, Lian, Zhang   +7 more
openaire   +2 more sources

Data_Sheet_1_Guidelines for the diagnosis and treatment of knee osteoarthritis with integrative medicine based on traditional Chinese medicine.docx

, 2023
Knee osteoarthritis (KOA) is a common geriatric disease in middle-aged and elderly people. Its main pathological characteristics are articular cartilage degeneration, changes in subchondral bone reactivity, osteophyte formation at joint edges, synovial ...
Lingfeng Zeng (3530336), Guanghui Zhou (1892779), Weiyi Yang (1418941), Jun Liu (42548)   +3 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Expert consensus statement on risk management for scraping treatment (刮痧意外情况处理专家共识)

, 2023
Scraping therapy has the therapeutic effect of dredging meridians, regulating viscera and eliminating toxins. Because of its many advantages, this therapy has become one of the most widely used external treatment methods of Traditional Chinese Medicine ...
Beijing Office of Traditional Chinese Medicine Nursing Competence Improvement Project (北京市中医护理能力提升工程办公室，北京市中医技术质控中心)
core   +1 more source

Integrating Time‐Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early risk stratification may support clinical decision‐making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time‐adjusted non‐contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90‐
Lei Song, Ren Ke, Anqi Chen, Yufei Fu, Hang Zhou, Rujia Wang, Liwei Zou, Yongqiang Yu, Ming Yuan, Xiaoming Qiu, Mengzhou Xue   +10 more
wiley   +1 more source

Application and thoughts of external application of integrated traditional Chinese and western medicine in wound treatment after breast and thyroid surgeries (中西医结合外治法在甲状腺和乳腺手术患者创面治疗中的应用与思考)

中西医结合护理, 2022
This paper overviewed the general situation of breast and thyroid surgery, summarized the postoperative wound complications and related non-surgical treatment, discussed the research status and development prospect of Traditional Chinese Medicine ...
GE Yunxia (葛云霞), WANG Bei (王蓓)
doaj   +1 more source