Results 51 to 60 of about 3,918,834 (249)

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

Advanced Science, EarlyView.
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui, Yuening Sun, Ziyang Liu, Xuntao Lai, Yunshu Zhao, Yan'er Wang, Yuanming He, Fang Xu, Du Feng, Longlong Liu, Zhenqian Huang, Lijie Xing, Xinliang Mao   +12 more
wiley   +1 more source

Links between mothers’ ACEs, their psychopathology and parenting, and their children’s behavior problems–A mediation model

Frontiers in Psychiatry, 2022
IntroductionChildren of mothers with a history of adverse childhoods are at greater risk of behavior problems. However, the mechanisms through which a mother’s early adverse experiences (ACEs) are transmitted to her children need further study.
Keren Hanetz-Gamliel, Daphna G. Dollberg
doaj   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Maternal Psychological Control and Rural Left-Behind Children's Anxiety: The Moderating Role of Externalizing Problem Behavior and Teacher Support

Frontiers in Psychology, 2021
Based on the risk and protective factor framework and context-dependent theory, the present study investigated the association between maternal psychological control and anxiety among left-behind children in rural China as well as the moderating roles of
Na Deng, Hongyan Bi, Jinxia Zhao
doaj   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Parental Burnout and Child Behavior: A Preliminary Analysis of Mediating and Moderating Effects of Positive Parenting

Children
Despite its significant growth over the past fifteen years, research on parental burnout is just beginning to explore the relationships of the syndrome with child behavior.
Aline Woine, María Josefina Escobar, Carolina Panesso, Dorota Szczygieł, Moïra Mikolajczak, Isabelle Roskam   +5 more
doaj   +1 more source

A Bi-Dimensional Taxonomy of Social Responsivity in Middle Childhood: Prosociality and Reactive Aggression Predict Externalizing Behavior Over Time

Frontiers in Psychology, 2021
Developing social skills is essential to succeed in social relations. Two important social constructs in middle childhood, prosocial behavior and reactive aggression, are often regarded as separate behaviors with opposing developmental outcomes. However,
Simone Dobbelaar, Simone Dobbelaar, Simone Dobbelaar, Simone Dobbelaar, Anna C. K. van Duijvenvoorde, Anna C. K. van Duijvenvoorde, Anna C. K. van Duijvenvoorde, Michelle Achterberg, Michelle Achterberg, Michelle Achterberg, Michelle Achterberg, Mara van der Meulen, Mara van der Meulen, Mara van der Meulen, Eveline A. Crone, Eveline A. Crone, Eveline A. Crone, Eveline A. Crone   +17 more
doaj   +1 more source

Field‐Driven Active Colloids as Distributed Micromachines: Bridging Physics, Control, and Function Across Length Scales

Advanced Science, EarlyView.
Field‐driven active colloids are framed as distributed micromachines in which externally supplied power, sensing, and control regulate task‐relevant states. By closing the loop between particle behavior, imaging, computation, and electric or magnetic actuation, these systems can progress from programmable motion toward adaptive functional outcomes ...
Ruchi Patel, Bhuvnesh Bharti
wiley   +1 more source

Children and adolescents with externalizing behavior in dental care [PDF]

, 2017
Aim: To study children/adolescents with externalizing behavior and a subgroup diagnosed ADHD, regarding oral health, oral health behavior, and the parents' evaluation on their child’s oral health and dental experience.
Staberg, Marie
core   +1 more source

Survey datasets on the externalizing behaviors of primary school pupils and secondary school students in some selected schools in Ogun State, Nigeria

Data in Brief, 2017
This data article contains the partial analysis (descriptive statistics) of data obtained from 1770 primary school pupils and secondary school students in three Local Government Areas of Ogun State, Nigeria.
Sheila A. Bishop, Enahoro A. Owoloko, Hilary I. Okagbue, Pelumi E. Oguntunde, Oluwole A. Odetunmibi, Abiodun A. Opanuga   +5 more
doaj   +1 more source