Results 121 to 130 of about 2,625,869 (258)

First extinction risk assessment of a bryophyte species in Antarctica

open access: yesOryx
Assessing extinction risk is important for protecting species, as it is the starting point for conservation efforts. However, in Antarctica, none of the c. 116 species of bryophytes (the main terrestrial plant group) have been assessed.
Eduardo T. Amorim   +4 more
doaj   +1 more source

Annual Report - Marine Biological Laboratory, 1983

open access: yes, 1983
Annual report of the Marine Biological Laboratory in Woods Hole. 1983.
Marine Biological Laboratory (Woods Hole MA)
core  

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

open access: yesAdvanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu   +3 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1894

open access: yes, 1895
Annual report of the Marine Biological Laboratory in Woods Hole. 1894.
Marine Biological Laboratory (Woods Hole MA)
core  

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu   +10 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1988

open access: yes, 1989
Annual report of the Marine Biological Laboratory in Woods Hole. 1988.
Marine Biological Laboratory (Woods Hole MA)
core  

An Optimized Freeze‐Dry Multimodal Workflow for Sequential Micro‐CT Imaging, Histology, and Molecular Profiling: A Use Case in Human Liver Fibrosis

open access: yesAdvanced Science, EarlyView.
Optimized freeze‐drying and eosin staining deliver artifact‐free micro‐CT images of liver tissue at near‐histological detail, then hand the same specimen back for sectioning, staining, and sequencing. Fibrotic volume distinguishes normal liver from cirrhosis, while preserved RNA reveals inflammatory gene upregulation—one biopsy, three dimensions, and a
Kristijan Skok   +13 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1935

open access: yes, 1936
Annual report of the Marine Biological Laboratory in Woods Hole. 1935.
Marine Biological Laboratory (Woods Hole MA)
core  

Carbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM

open access: yesAdvanced Science, EarlyView.
Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...
Haobo Ge   +13 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1943

open access: yes, 1944
Annual report of the Marine Biological Laboratory in Woods Hole. 1943.
Marine Biological Laboratory (Woods Hole MA)
core  

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