Results 271 to 280 of about 935,910 (334)
Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles
Advanced Science, EarlyView.This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.Vadim Le Joncour, Austin D. Evans, Camilla Karoliina Bergström, Vignesh Kumar Rangasami, Sumanta Samanta, Nithiyanandan Krishnan, Yuji Teramura, Bo Nilsson, Patricia Hedenqvist, Elin Manell, Jons Hilborn, Marianne‐Jensen Waern, Oommen P. Varghese, Pirjo Laakkonen, Oommen P. Oommen +14 morewiley +1 more sourceExtended Data Fig. 3 in one-quarter of freshwater fauna threatened with extinction
Catherine A. Sayer, Eresha Fernando, Randall R. Jiménez, Nicholas B. W. Macfarlane, Giovanni Rapacciuolo, Monika Böhm, Thomas M. Brooks, Topiltzin Contreras‐MacBeath, Neil A. Cox, Ian Harrison, Michael Hoffmann, RICHARD JENKINS, Kevin G. Smith, Jean-Christophe Vie, John C. Abbott, David J. Allen, Gerald R. Allen, Violeta Barrios, Jean-Pierre Boudot, Savrina F Carrizo, Patricia Charvet, Viola Clausnitzer, Leonardo Congiu, Keith A. Crandall, Neil Cumberlidge, Annabelle Cuttelod, JAMES DALTON, Adam G. Daniels, Sammy De Grave, Geert De Knijf, Klaas‐Douwe B. Dijkstra, Rory A. Dow, Jörg Freyhof, Nieves Garcia, Joern Gessner, Abebe Getahun, Claudine Gibson, Matthew J. Gollock, MichaelI. Grant, Alice E. R. Groom, Michael P. Hammer, Geoffrey A. Hammerson, Craig Hilton-Taylor, Laurel Hodgkinson, Robert A. Holland, Rima W. Jabado, Diego Juffe-Bignoli, Vincent J. Kalkman, Bakhtiyor K. Karimov, Jens Kipping, Maurice Kottelat, Philippe A. Lalèyè, Helen K. Larson, Mark Lintermans, Federico Lozano, Arne Ludwig, Timothy J. Lyons, Laura Máiz-Tomé, Sanjay Molur, Heok Hee Ng, Catherine Numa, Amy F. Palmer-Newton, Charlotte Pike, Helen E. Pippard, Carla N. M. Polaz, Caroline M. Pollock, Rajeev Raghavan, Peter S. Rand, Tsilavina Ravelomanana, Roberto E. Reis, Cassandra L. Rigby, Janet A. Scott, Paul H. Skelton, Matthew R. Sloat, Jos Snoeks, Melanie L. J. Stiassny, Heok Hui Tan, Yoshinori Taniguchi, Eva B. Thorstad, Marcelo F. Tognelli, Armi G. Torres, Yan Torres, Denis Tweddle, Katsutoshi Watanabe, James R. S. Westrip, Emma G. E. Wright, E. Zhang, William R. T. Darwall +87 moreopenalex +1 more sourceTBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration
Advanced Science, EarlyView.Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer +10 morewiley +1 more sourceFig. 2 in one-quarter of freshwater fauna threatened with extinction
Catherine A. Sayer, Eresha Fernando, Randall R. Jiménez, Nicholas B. W. Macfarlane, Giovanni Rapacciuolo, Monika Böhm, Thomas M. Brooks, Topiltzin Contreras-Macbeath, Neil A. Cox, Ian Harrison, Michael Hoffmann, Richard Jenkins, Kevin G. Smith, Jean Christophe Vié, John C. Abbott, David J. Allen, Gerald R. Allen, Violeta Barrios, Jean-Pierre BOUDOT, Savrina F Carrizo, Patricia Charvet, Viola Clausnitzer, Leonardo Congiu, Keith A. Crandall, Neil Cumberlidge, Annabelle Cuttelod, James Dalton, Adam G. Daniels, Sammy de Grave, Geert De Knijf, Klaas-Douwe B. Dijkstra, Rory A. Dow, Jörg Freyhof, Nieves García, Joern Gessner, Abebe Getahun, Claudine Gibson, Matthew J. Gollock, MichaelI. Grant, Alice E. R. Groom, Michael P. Hammer, Geoffrey A. Hammerson, Craig Hilton-Taylor, Laurel Hodgkinson, Robert A. Holland, Rima W. Jabado, Diego Juffe-Bignoli, Vincent J. Kalkman, Bakhtiyor K. Karimov, Jens Kipping, Maurice Kottelat, Philippe A. Lalèyè, Helen K Larson, Mark Lintermans, Federico Lozano, Arne Ludwig, Timothy J. Lyons, Laura Máiz-Tomé, Sanjay Molur, HEOK HEE NG, Catherine Numa, Amy F. Palmer-Newton, Charlotte Pike, Helen E. Pippard, Carla N. M. Polaz, Caroline M. Pollock, Rajeev Raghavan, Peter S. Rand, Tsilavina Ravelomanana, Roberto E. Reis, Cassandra L. Rigby, Janet A Scott, Paul H. Skelton, Matthew R. Sloat, Jos Snoeks, Melanie L. J. Stiassny, Heok Hui Tan, Yoshinori Taniguchi, Eva B. Thorstad, Marcelo F. Tognelli, Armi G. Torres, Yan Torres, Denis Tweddle, Katsutoshi Watanabe, James R.S. Westrip, Emma G. E. Wright, E Zhang, William R. T. Darwall +87 moreopenalex +1 more sourceBalanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica
Advanced Science, EarlyView.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu +9 morewiley +1 more sourceFoldable Soft Leg‐Assisted Wheel Robot
Advanced Science, EarlyView.Recently, soft robots garner attention for designing the robotic legs of mobile robots due to their characteristic lightness, tunability, and simple control. Here, a novel soft foldable leg capable of high stiffness and deformability is identified as an assistant for enhancing the locomotion capabilities of a wheel mobile robot.Seunghoon Yoo, Sohyun Kim, Joohyeon Kang, Hyunjun Park, Seokjun Lee, Youngsu Cha +5 morewiley +1 more source
