Results 101 to 110 of about 7,491,645 (339)
Advanced Healthcare Materials, EarlyView.Six stereoisomeric ruthenium‐peptide conjugates were synthesized and characterized, which showed high potential in photoactivated chemotherapy (PACT) and proximity protein labeling. Abstract Amino acid chirality is known to influence the biological properties of peptide‐containing prodrugs.
Liyan Zhang +7 more
wiley +1 more source
Aquatic refuges for surviving a global catastrophe [PDF]
, 2017 Recently many methods for reducing the risk of human extinction have been suggested, including building refuges underground and in space. Here we will discuss the perspective of using military nuclear submarines or their derivatives to ensure the ...
Green, Brian, Turchin, Alexey
core +1 more source
Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization
Advanced Healthcare Materials, EarlyView.A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng
Molood Behbahanipour +11 more
wiley +1 more source
An Ultrapotent, Ultraeconomical, Antifreeze Polypeptide
Advanced Materials, EarlyView.Simple and inexpensive polypeptides composed of random copolymers of alanine and glutamic acid are effective antifreezes for applications in foods and biomedicine. The polypeptides, inspired by natural extremophile proteins, inhibit the growth of large ice crystals and prevent damage to sensitive biologics.
Thomas J. McPartlon +5 more
wiley +1 more source
On population extinction risk in the aftermath of a catastrophic event
, 2008 We investigate how a catastrophic event (modeled as a temporary fall of the reproduction rate) increases the extinction probability of an isolated self-regulated stochastic population.
Alex Kamenev +8 more
core +1 more source
Using food-web theory to conserve ecosystems [PDF]
, 2015 © 2016, Nature Publishing Group. All rights reserved.Food-web theory can be a powerful guide to the management of complex ecosystems. However, we show that indices of species importance common in food-web and network theory can be a poor guide to ...
McDonald-Madden, E, Possingham, HP
core +1 more source
Plants, People, PlanetSocietal Impact Statement Native medicinal plants contribute essential health benefits to populations globally, constituting a major natural resource that human societies rely on.
Spyros Theodoridis +2 more
doaj +1 more source
Risk of Population Extinction from Periodic and Abrupt Changes of Environment
, 2008 A simulation model of a population having internal (genetic) structure is presented. The population is subject to selection pressure coming from the environment which is the same in the whole system but changes in time.
Andrzej Pękalski +26 more
core +1 more source
Quiescence: a mechanism for escaping the effects of drug on cell populations [PDF]
, 2010 We point out that a simple and generic strategy to lower the risk for extinction consists in the developing a dormant stage in which the organism is unable to multiply but may die. The dormant organism is protected against the poisonous environment.
Alberts B. +4 more
core +4 more sources