Results 81 to 90 of about 293,102 (343)
Quiescence: a mechanism for escaping the effects of drug on cell populations [PDF]
, 2010 We point out that a simple and generic strategy to lower the risk for extinction consists in the developing a dormant stage in which the organism is unable to multiply but may die. The dormant organism is protected against the poisonous environment.
Alberts B. +4 more
core +4 more sources
Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization
Advanced Healthcare Materials, EarlyView.A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng
Molood Behbahanipour +11 more
wiley +1 more source
Advances in Safe, Flexible, and Stretchable Batteries for Wearable Applications
Advanced Materials Technologies, EarlyView.Unlike previous reviews centered on component‐based deformability, this work highlights safety‐driven design strategies for flexible and stretchable batteries. By integrating material‐level engineering, geometry‐controlled structures, biocompatibility, and self‐protection mechanisms, it establishes a unified framework that connects mechanical ...
Hyewon Kang +4 more
wiley +1 more source
Advanced Science, EarlyView.Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance +17 more
wiley +1 more source
On population extinction risk in the aftermath of a catastrophic event
, 2008 We investigate how a catastrophic event (modeled as a temporary fall of the reproduction rate) increases the extinction probability of an isolated self-regulated stochastic population.
Alex Kamenev +8 more
core +1 more source
Drivers of extinction risk in African mammals: the interplay of distribution state, human pressure, conservation response and species biology [PDF]
, 2014 Although conservation intervention has reversed the decline of some species, our success is outweighed by a much larger number of species moving towards extinction.
BOITANI Luigi +8 more
core +1 more source
Advanced Science, EarlyView.This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang +9 more
wiley +1 more source
Risk of Population Extinction from Periodic and Abrupt Changes of Environment
, 2008 A simulation model of a population having internal (genetic) structure is presented. The population is subject to selection pressure coming from the environment which is the same in the whole system but changes in time.
Andrzej Pękalski +26 more
core +1 more source
Relative Extinction of Heterogeneous Agents [PDF]
, 2009 In all the existing literature on survival in heterogeneous economies, the rate at which an agent vanishes in the long run relative to another agent can be characterized by the difference of the so-called survival indices, where each survival index ...
Cvitanić, Jakša, Malamud, Semyon
core +1 more source
Advanced Science, EarlyView.IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu +9 more
wiley +1 more source