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Extracellular Matrix and Ageing
2018The extracellular matrix (ECM) provides the environment for many cells types within the body and, in addition to the well recognised role as a structural support, influences many important cell process within the body. As a result, age-related changes to the proteins of the ECM have far reaching consequences with the potential to disrupt many different
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Extracellular matrix (ECM) stiffness and degradation as cancer drivers
Journal of Cellular Biochemistry, 2018Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The alterations toward both stiffness and degradation are contributed to tumor growth and progression.
M. Najafi, Bagher Farhood, K. Mortezaee
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Cell–extracellular matrix mechanotransduction in 3D
Nature reviews. Molecular cell biology, 2023Aashrith Saraswathibhatla +2 more
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Regulation of extracellular matrix degradation by cell—extracellular matrix interactions
Cell Differentiation and Development, 1990An appropriate balance of extracellular matrix synthesis and degradation is required for normal morphogenesis and maintenance of tissue architecture. Extracellular matrix molecules and their receptors, as well as proteinases and their inhibitors, are all involved in matrix remodeling.
Zena Werb +5 more
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[Phylogenesis of the extracellular matrix].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1993The extracellular matrix constitutes a highly organized intercellular medium. In multicellular animals, it plays important functions for cell cohesion and for the modulation of cell differentiation and behaviour as well. All the investigations conducted in non-vertebrate species have shown that the extracellular matrix is present at the onset of the ...
Garrone, R. +6 more
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The extracellular matrix: Summation
Journal of Cardiac Failure, 2002The development and progression oflef t ventricular (LV) dysfunction and, ultimately, the clinical manifestation ofcongestive heart f (CHF) is due to the summation ofa number ofsystemic, cellular, and molecular abnormalities. The specific constellation ofabnormalities that contribute to the progression ofCHF is disease dependent, but it likely includes
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Annual Review of Cell and Developmental Biology, 1988
Fibronectin remains unique among matrix components because it exists in both soluble and matrix forms. It seems likely that the necessity to prevent inappropriate matrix assembly from soluble fibronectin results in a strict requirement for catalysis by specific cells to deposit fibronectin fibrils.
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Fibronectin remains unique among matrix components because it exists in both soluble and matrix forms. It seems likely that the necessity to prevent inappropriate matrix assembly from soluble fibronectin results in a strict requirement for catalysis by specific cells to deposit fibronectin fibrils.
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The extracellular matrix and atherosclerosis
Current Opinion in Lipidology, 1995The vascular extracellular matrix is a collection of vastly different macromolecules organized by entanglement and cross-linking into a biomechanically active polymer that imparts regional tensile strength, viscoelasticity, and compressibility to the atherosclerotic lesion.
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The extracellular matrix is instructive
BioEssays, 1986AbstractThe extracellular matrix does more than just blanket cells; it also provides informational cues which affect a variety of developmental and cellular maintenance activities. The constituents of the matrix provide the fabric for cell motility and cell shape as well as anchorage sites for bioactive factors which directly affect the cell's ...
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The plant extracellular matrix
Current Opinion in Cell Biology, 1989There is a lot of extmcellular matrix (EM) about, and most of it surrounds plant cells. But, despite its importance in functions ranging .from morphogenesis to pathogen resistance, relatively little work has been directed towards it at a cell biological level.
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