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THE EXTRACELLULAR SPACE IN EXPERIMENTAL BRAIN TUMORS
Acta Neurologica Scandinavica, 1971Experimental brain tumors were produced in mice with 20–methyl cholanthrene, and the uptake of radioactive extracellular markers was studied by tissue assay and autoradiography. The tracers included C14-sucrose, C14-inulin, and H3inulin. The water content and isotope concentration of both gliomas and meningiomas were higher than those of normal brain ...
T, Kobayashi, L, Bakay
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Extracellular Brain Space Measured by S35 Sulfate
Archives of Neurology, 1961Introduction Electron miscroscopic studies of the central nervous system have emphasized the virtual absence of detectable extracellular spaces. 1-4 These observations have provoked dissatisfaction with the chloride ion as an indicator of the extracellular space of brain.
C F, BARLOW +3 more
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The determination of extracellular space using hemoglobin
Experientia, 1978The ECS of guinea-pig atria and frog sartorii can be determined using hemoglobin. For guinea-pig atria an ECS of (32.2 +/- 2.6)% wet wt for frog sartorii an ECS of (12.4 +/- 1.0)% wet wt can be measured.
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The extracellular space and matrix of gliomas
Acta Neuropathologica, 2005Changes in the properties of extracellular space (ECS)--its volume, shape, and composition--play an important role in influencing the biological behavior of brain tumors. Experimental methods allowing assessment of the volume and geometry of ECS by means of analyzing the diffusion of molecules within ECS have revealed a dramatic increase in the ECS ...
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Extracellular superoxide dismutase (SOD3): An antioxidant or prooxidant in the extracellular space?
2020Superoxide dismutase 3 (SOD3 or EC-SOD) is the only scavenger of superoxide in the extracellular space allowing for the catalyzed dismutation of the superoxide radical into hydrogen peroxide. The activity and distribution of the enzyme are regulated at several levels, suggesting the need for balanced activity in the extracellular space.
Zachariae, Elias Didrik Francis M +2 more
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Brain extracellular space fixed for electron microscopy
Neuroscience Letters, 1979Adult mammalian brain contains 17--20% extracellular space, but fixatives cause the cellular elements to ingest the extracellular fluid so that the space is reduced to less than 5% with all conventional methods of fixation. This can be prevented by washing out the extracellular fluid with isotonic sucrose, which does not penetrate cells.
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EXTRACELLULAR SPACE IN THE CENTRAL NERVOUS SYSTEM
Archives of Neurology And Psychiatry, 1955A KNOWLEDGE of the volume and composition of the extracellular space in brain substance is of considerable importance in any investigation dealing with electrolyte concentrations in nerve tissue and with mechanisms of fluid shifts in cerebral edema. Although fluid partitions have been thoroughly studied in the body as a whole, and in muscle tissue in ...
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Responsive materials architected in space and time
Nature Reviews Materials, 2022Xiaoxing Xia +2 more
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