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Dynamics of extrachromosomal circular DNA in rice [PDF]

Nature Communications
The genome’s dynamic nature, exemplified by elements like extrachromosomal circular DNA (eccDNA), is crucial for biodiversity and adaptation. Yet, the role of eccDNA in plants, particularly rice, remains underexplored.
Jundong Zhuang, Yaoxin Zhang, Congcong Zhou, Danlin Fan, Tao Huang, Qi Feng, Yiqi Lu, Yan Zhao, Qiang Zhao, Bin Han, Tingting Lu   +10 more
doaj   +3 more sources

The extrachromosomal circular DNA atlas of aged and young mouse brains [PDF]

Scientific Data
Extrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation ...
Xiaoning Hong, Jing Li, Peng Han, Shaofu Li, Jiaying Yu, Haoran Zhang, Jiang Li, Yonghui Dang, Xi Xiang   +8 more
doaj   +3 more sources

Categorizing Extrachromosomal Circular DNA as Biomarkers in Serum of Cancer [PDF]

Biomolecules
Extrachromosomal circular DNA (eccDNA), a double-stranded circular DNA molecule found in multiple organisms, has garnered an increasing amount of attention in recent years due to its close association with the initiation, malignant progression, and ...
Enze Deng, Xiaoying Fan
doaj   +3 more sources

Extrachromosomal circular DNA containing DTX1 promotes cell growth in hydroquinone-induced malignantly transformed cells by regulating the transcription of DTX1 [PDF]

BMC Cancer
Background Extrachromosomal circular DNA (eccDNA), a novel class of DNA with a circular topological structure, is present in a variety of cancer cells and tissues and may play broad roles in processes ranging from aging to cancer cell heterogeneity ...
Xiaoxuan Ling, Qunfang Jiao, Daifan Lin, Jialong Chen, Yali Han, Jinxue Meng, Bohuan Zhong, He Zhang, Gongda Zhang, Fangling Zhu, Jiheng Qin, Yongdui Ruan, Linhua Liu   +12 more
doaj   +3 more sources

Characterization, biogenesis model, and current bioinformatics of human extrachromosomal circular DNA [PDF]

Frontiers in Genetics
Human extrachromosomal circular DNA, or eccDNA, has been the topic of extensive investigation in the last decade due to its prominent regulatory role in the development of disorders including cancer. With the rapid advancement of experimental, sequencing
Lina Zhou, Wenyi Tang, Bo Ye, Lingyun Zou, Lingyun Zou   +4 more
doaj   +3 more sources

TeCD: The eccDNA Collection Database for extrachromosomal circular DNA

BMC Genomics, 2023
Background Extrachromosomal circular DNA (eccDNA) is a kind of DNA that widely exists in eukaryotic cells. Studies in recent years have shown that eccDNA is often enriched during tumors and aging, and participates in the development of cell physiological
Jing Guo, Ze Zhang, Qingcui Li, Xiao Chang, Xiaoping Liu   +4 more
doaj   +2 more sources

Extrachromosomal circular DNA orchestrates genome heterogeneity in urothelial bladder carcinoma. [PDF]

Theranostics
Rationale: Extrachromosomal circular DNA is a hallmark of cancer, but its role in shaping the genome heterogeneity of urothelial bladder carcinoma (UBC) remains poorly understood.
Lv W, Pan X, Han P, Wu S, Zeng Y, Wang Q, Guo L, Xu M, Qi Y, Deng L, Xu Z, Li C, Yu T, Cui X, Teng H, Xiang C, Tan H, Li Y, Liang N, Tao H, Gao Q, Yu G, Mi J, Xu F, Gong B, Shi L, Wang T, Yang H, Dong W, Bolund L, Lin L, Wang W, Li H, Huang J, Lin C, Luo Y.   +35 more
europepmc   +2 more sources

Extrachromosomal circular DNA: biogenesis, structure, functions and diseases

Signal Transduction and Targeted Therapy, 2022
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base pairs, is independent of conventional chromosomes. Recently, eccDNAs have been considered an unanticipated major source of somatic rearrangements, contributing to ...
Ludi Yang, Ruobing Jia, Tongxin Ge, Shengfang Ge, Ai Zhuang, Peiwei Chai, Xianqun Fan   +6 more
doaj   +2 more sources

Extrachromosomal Circular DNA (eccDNA): From Chaos to Function

Frontiers in Cell and Developmental Biology, 2022
Extrachromosomal circular DNA (eccDNA) is a type of double-stranded circular DNA that is derived and free from chromosomes. It has a strong heterogeneity in sequence, length, and origin and has been identified in both normal and cancer cells.
Shanru Zuo, Shanru Zuo, Yihu Yi, Chen Wang, Xueguang Li, Mingqing Zhou, Qiyao Peng, Qiyao Peng, Junhua Zhou, Yide Yang, Quanyuan He   +10 more
doaj   +2 more sources

Extrachromosomal circular DNA: a new potential role in cancer progression

Journal of Translational Medicine, 2021
Extrachromosomal circular DNA (eccDNA) is considered a circular DNA molecule that exists widely in nature and is independent of conventional chromosomes. eccDNA can be divided into small polydispersed circular DNA (spcDNA), telomeric circles (t-circles),
Tianyi Wang, Haijian Zhang, Youlang Zhou, Jiahai Shi   +3 more
doaj   +2 more sources