Results 1 to 10 of about 13,987 (204)

Extrachromosomal Circular DNA: Category, Biogenesis, Recognition, and Functions [PDF]

Frontiers in Veterinary Science, 2021
Extrachromosomal circular DNA (eccDNA), existing as double-stranded circular DNA, is derived and free from chromosomes. It is common in eukaryotes but has a strong heterogeneity in count, length, and origin.
Xiukai Cao, Shan Wang, Ling Ge, Weibo Zhang, Jinlin Huang, Wei Sun, Wei Sun   +6 more
doaj   +4 more sources

Dynamics of extrachromosomal circular DNA in rice [PDF]

Nature Communications
The genome’s dynamic nature, exemplified by elements like extrachromosomal circular DNA (eccDNA), is crucial for biodiversity and adaptation. Yet, the role of eccDNA in plants, particularly rice, remains underexplored.
Jundong Zhuang, Yaoxin Zhang, Congcong Zhou, Danlin Fan, Tao Huang, Qi Feng, Yiqi Lu, Yan Zhao, Qiang Zhao, Bin Han, Tingting Lu   +10 more
doaj   +4 more sources

Comparative analysis of methodologies for detecting extrachromosomal circular DNA [PDF]

Nature Communications
Extrachromosomal circular DNA (eccDNA) is crucial in oncogene amplification, gene transcription regulation, and intratumor heterogeneity. While various analysis pipelines and experimental methods have been developed for eccDNA identification, their ...
Xuyuan Gao, Ke Liu, Songwen Luo, Meifang Tang, Nianping Liu, Chen Jiang, Jingwen Fang, Shouzhen Li, Yanbing Hou, Chuang Guo, Kun Qu   +10 more
doaj   +4 more sources

Research Advances of Extrachromosomal Circular DNA in Breast Cancer [PDF]

Cancer Medicine
Background This article presents an extensive review of the advancements in research concerning extrachromosomal circular DNA (ecDNA) within the context of breast cancer.
Xiaodan Zhu, Yiyang Qian, Quan Tang, Jiahui Li, Yuqing Geng, Shixia Gong, Chunhui Jin   +6 more
doaj   +3 more sources

Distribution and characterization of extrachromosomal circular DNA in colorectal cancer [PDF]

Molecular Biomedicine, 2022
Extrachromosomal circular DNA (eccDNA) has been shown to play an important role in the amplification of tumor genes and the maintenance of intra-tumor genetic heterogeneity, although its complex functional mechanism still remains to be elucidated. As the
Zhehang Chen, Yadong Qi, Jiamin He, Chaochao Xu, Qiwei Ge, Wei Zhuo, Jianmin Si, Shujie Chen   +7 more
doaj   +4 more sources

Extrachromosomal circular DNA as a novel biomarker for the progression of colorectal cancer [PDF]

Molecular Medicine
Background Extrachromosomal circular DNA (eccDNA) has potential in tumor diagnosis, particularly for improving diagnostic accuracy and early cancer detection; however, many challenges remain in its application to clinical practice. Methods We conducted a
Quanpeng Qiu, Yi Ding, Xiaolong Guo, Jing Han, Jiaqi Zhang, Yaping Liu, Junjun She, Yinnan Chen   +7 more
doaj   +4 more sources

Extrachromosomal Circular DNA as a Cancer Biomarker: From Diagnosis to Treatment [PDF]

Cancer Innovation
Extrachromosomal circular DNA (eccDNA) is an emerging class of genetic material that exists outside of the chromosomal genome. These circular DNA molecules are gaining increasing attention as important biomarkers in various cancers because of their roles
Hexin Li, Jiahui Cai, Gang Zhao, Lihui Zou   +3 more
doaj   +2 more sources

The extrachromosomal circular DNA atlas of aged and young mouse brains [PDF]

Scientific Data
Extrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation ...
Xiaoning Hong, Jing Li, Peng Han, Shaofu Li, Jiaying Yu, Haoran Zhang, Jiang Li, Yonghui Dang, Xi Xiang   +8 more
doaj   +2 more sources

Extrachromosomal circular DNA expressing miRNA promotes ovarian cancer progression [PDF]

Clinical and Translational Medicine
Background Extrachromosomal circular DNA (eccDNA) has emerged as a critical driver of oncogenesis, yet its functional roles in high‐grade serous ovarian cancer (HGSOC) remain poorly characterized. This highlights the need for comprehensive investigations
Ning Wu, Ling Wei, Qiyu Liu, Tianhui He, Cuiyu Huang, Yunpeng Jiang, Kailong Li, Hongyan Guo, Fengbiao Mao, Xiaolu Zhao   +9 more
doaj   +2 more sources

Extrachromosomal Circular DNA and Transposable Elements in Type 2 Diabetes. [PDF]

Int J Mol Sci
Moya-Valera C, Arita AF, Lara-Hernández F, García-García AB, Chaves FJ.   +4 more
europepmc   +2 more sources