Advanced Science, Volume 12, Issue 25, July 3, 2025.Extrachromosomal Circular DNA In article number 2501934, Bin Shi, Shuyu Zhang, and co‐workers present the increased existence of eccDNA induced by ionizing radiation. VPS41 gene in the eccDNA confers protection against genotoxic stress. This study highlights the role of eccDNA in cellular defense, providing strategies to enhance tissue resilience to ...
Bin Shi +12 more
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Therapies for Mitochondrial Disease: Past, Present, and Future
Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.ABSTRACT Mitochondrial disease is a diverse group of clinically and genetically complex disorders caused by pathogenic variants in nuclear or mitochondrial DNA‐encoded genes that disrupt mitochondrial energy production or other important mitochondrial pathways. Mitochondrial disease can present with a wide spectrum of clinical features and can often be
Megan Ball +5 more
wiley +1 more source
Integration of the blaNDM-1 carbapenemase gene into Proteus genomic island 1 (PGI1-PmPEL) in a Proteus mirabilis clinical isolate [PDF]
, 2015 Objectives To decipher the mechanisms and their associated genetic determinants responsible for β-lactam resistance in a Proteus mirabilis clinical isolate.
Dortet, Laurent +3 more
core +2 more sources
Agricultural biotechnology: Potential, challenges, and debate
PLANTS, PEOPLE, PLANET, EarlyView.
Marjorie R. Lundgren +2 more
wiley +1 more source
FEBS Open Bio, Volume 15, Issue 6, Page 906-913, June 2025.Heterologous expression of membrane transporters in cultured cells is essential for functional characterization, but is sometimes limited by low activity. Our study compares the HDAC inhibitors butyrate, VPA and SAHA to enhance transport activity. We propose to replace butyrate by SAHA: it is equally effective, devoid of repulsive odor, costs less, and
Svenja Flögel +4 more
wiley +1 more source
Extrachromosomal Circular DNA from TCGA Tumors Is Generated from Common Genomic Loci, Is Characterized by Self-Homology and DNA Motifs near Circle Breakpoints [PDF]
, 2022 Philip D. Tatman, Joshua C. Black
openalex +1 more source
ECCsplorer: a pipeline to detect extrachromosomal circular DNA (eccDNA) from next-generation sequencing data [PDF]
, 2022 Ludwig Mann +3 more
openalex +1 more source
Native Plasmid-Encoded Mercury Resistance Genes Are Functional and Demonstrate Natural Transformation in Environmental Bacterial Isolates. [PDF]
, 2019 Plasmid-mediated horizontal gene transfer (HGT) is a major driver of genetic diversity in bacteria. We experimentally validated the function of a putative mercury resistance operon present on an abundant 8-kbp native plasmid found in groundwater samples ...
Carlson, Hans K +5 more
core +1 more source
Identification and characterization of extrachromosomal circular DNA in alcohol induced osteonecrosis of femoral head [PDF]
, 2022 Tingting Zhou +6 more
openalex +1 more source
Urinary cell‐free extrachromosomal circular DNAs: A possible biomarker for chronic kidney disease [PDF]
, 2022 Selami Demirci
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