Results 171 to 180 of about 13,987 (204)

Characterization, biogenesis model, and current bioinformatics of human extrachromosomal circular DNA. [PDF]

Front Genet
Zhou L, Tang W, Ye B, Zou L.
europepmc   +1 more source

Beyond the Chromosome: Recent Developments in Decoding the Significance of Extrachromosomal Circular DNA (eccDNA) in Human Malignancies. [PDF]

Life (Basel)
Tsiakanikas P, Athanasopoulou K, Darioti IA, Agiassoti VT, Theocharis S, Scorilas A, Adamopoulos PG.   +6 more
europepmc   +1 more source

Comparative Analysis of Active LTR Retrotransposons in Sunflower (Helianthus annuus L.): From Extrachromosomal Circular DNA Detection to Protein Structure Prediction. [PDF]

Int J Mol Sci
Kazancev M, Merkulov P, Tiurin K, Demurin Y, Soloviev A, Kirov I.   +5 more
europepmc   +1 more source

Circle-map profiling of extrachromosomal circular DNA as diagnostic biomarkers for lung cancer. [PDF]

Precis Clin Med
Yang Y, Song T, Liu S, Liu Z, Wang X, Li Y, Liu D.   +6 more
europepmc   +1 more source

Extrachromosomal circular DNA promotes prostate cancer progression through the FAM84B/CDKN1B/MYC/WWP1 axis. [PDF]

Cell Mol Biol Lett
Jin W, Xu Z, Song Y, Chen F.
europepmc   +1 more source

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Gene amplifications and extrachromosomal circular DNAs: function and biogenesis

Molecular Biology Reports, 2023
Gene amplification is an increase in the copy number of restricted chromosomal segments that contain gene(s) and frequently results in the over-expression of the corresponding gene(s). Amplification may be found in the form of extrachromosomal circular DNAs (eccDNAs) or as linear repetitive amplicon regions that are integrated into chromosomes, which ...
Ali Yüksel, Oğuz Altungöz
openaire   +3 more sources

Extrachromosomal Circular DNAs, Amplified Oncogenes, and CRISPR-Cas9 System

Molecular Pharmacology, 2022
Structurally rearranged extrachromosomal circular DNAs (eccDNAs) have been identified in tumor cells, many of which carry regions related to recurrent cancer driver oncogenes (e.g., CCND1, EGFR, and MYC). In a tumor cell, eccDNAs are carrying regions associated with oncogene amplification (>10-fold amplified-copy numbers in human tumors) and poor ...
Fatemeh, Pourrajab, Mohamad Reza, Zare-Khormizi   +1 more
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Extrachromosomal Circular DNA and Aging Cells

1985
A DNA sequence situated in the human genome between Alu-repeat clusters ("Inter-Alu" DNA) is progressively amplified in extrachromosomal DNA, including covalently closed DNA circles, during serial passage of diploid fibroblasts. A single size-class of Inter-Alu circles is also amplified in lymphocytes from 16 of 24 old donors and yet is not detected in
C K, Lumpkin, J R, McGill, K T, Riabowol, E J, Moerman, R J, Shmookler Reis, S, Goldstein   +5 more
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Extrachromosomal circular DNAs from murine hemopoietic tissue cells

Plasmid, 1983
Extrachromosomal circular DNA complexes from cells of murine hemopoietic organs, bone marrow, thymus, spleen, and lymph nodes were examined by mica-press-adsorption method (H. Yamagishi, T. Kunisada, and T. Tsuda, 1982, Plasmid 8, 299-306). They showed wide size distribution, from 0.3 to 10 micron.
T, Tsuda, H, Yamagishi, N, Ohnishi, Y, Yamada, H, Izumi, K J, Mori   +5 more
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Purification of eucaryotic extrachromosomal circular DNAs using exonuclease III

Analytical Biochemistry, 1990
A method for the isolation of eucaryotic extrachromosomal circular (ecc) DNA is described. Exonuclease III was used to preparatively digest linear and open circular forms of DNA; the resultant exonuclease-resistant molecules were then characterized by buoyant density gradient sedimentation and were found to be essentially covalently closed circular DNA.
J W, Gaubatz, S C, Flores
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