Results 201 to 210 of about 2,048,993 (218)

Extrachromosomal DNA: Redefining the pathogenesis of glioblastoma

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021
Glioblastoma is an incurable most prevalent primary malignant brain tumor in adults. Surgery followed by radiotherapy with concomitant chemotherapy is the standard of care in patients with glioblastoma. Although, prognosis remains poor with a median survival in the range of 12-15 months.
Anjali, Shiras, Abir, Mondal
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The Extrachromosomal DNAs of Apicomplexan Parasites

Annual Review of Microbiology, 1994
Molecular analyses in recent years have begun to elucidate the identity and role of two extrachromosomal DNAs found in apicomplexan parasites. One of these is a small tandemly repeated DNA that encodes three classical mitochondrial protein coding genes, attesting to its identity.
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Extrachromosomal Circular DNA and Aging Cells

1985
A DNA sequence situated in the human genome between Alu-repeat clusters ("Inter-Alu" DNA) is progressively amplified in extrachromosomal DNA, including covalently closed DNA circles, during serial passage of diploid fibroblasts. A single size-class of Inter-Alu circles is also amplified in lymphocytes from 16 of 24 old donors and yet is not detected in
C K, Lumpkin, J R, McGill, K T, Riabowol, E J, Moerman, R J, Shmookler Reis, S, Goldstein   +5 more
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Progress on the role of extrachromosomal DNA in tumor pathogenesis and evolution

Clinical Genetics, 2020
The amplification of oncogenes on extrachromosomal DNA (ecDNA) provides a new mechanism for cancer cells to adapt to the changes in the tumor microenvironment and accelerate tumor evolution.
Jichen Xing, Qian Ning, Diya Tang, Zhongcheng Mo, X. Lei, Shengsong Tang   +5 more
semanticscholar   +1 more source

Chromothripsis Generates Oncogene-Containing Extrachromosomal DNA

Cancer Discovery, 2021
Abstract Chromothripsis (chromosome shattering) produced extrachromosomal DNA with amplified oncogenes.
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[Extrachromosomal DNA in yeast-Saccharomyces].

Molekuliarnaia biologiia, 1983
The recombinant plasmids containing autonomously replicating sequence (ARS) of yeast rDNA repeat are characterized by a high instability in transformed yeast cells. The instability of chimaric plasmids in yeast may result from improper replication and/or irregular mitotic segregation. To study the replication properties alone we have constructed series
V L, Larionov, N Iu, Kuprina, M N, Traugott   +2 more
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The genomic and spatial mobility of extrachromosomal DNA and its implications for cancer therapy

Nature Genetics, 2022
Eric van Leen, Lotte Brückner, A. Henssen   +2 more
semanticscholar   +1 more source

Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges

Nature Reviews Clinical Oncology, 2022
I. Noorani, P. Mischel, C. Swanton
semanticscholar   +1 more source

Extrachromosomal DNA

Journal of Supramolecular Structure, 1979
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[Extrachromosomal DNA in mammalian cells].

Tsitologiia, 1991
Extrachromosomal DNA (eDNA) is mammalian cells is represented not only as mitochondrial DNA but also as circular DNA existing both in the nucleus and in the cytoplasm. According to its size eDNA could be divided into two major classes: small polydisperse circular DNAs and large circular DNAs.
openaire   +1 more source