Results 91 to 100 of about 50,380 (239)

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio   +38 more
wiley   +1 more source

Assessment of Thrombin Generation in Pediatric Patients on Extracorporeal Life Support: Impact of Bivalirudin and Other Anticoagulants

open access: yesInternational Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Bivalirudin is an alternative anticoagulant to heparin and is widely used in pediatric extracorporeal life support (ECLS). Its activity is monitored using activated partial thromboplastin time (aPTT) and/or more specific tests such as plasma‐diluted thrombin time (dTT).
Vadim Kostousov   +3 more
wiley   +1 more source

Negotiated Ventilation: Conceptualising Interprofessional Decision Work in Intensive Care—An Ethnographic Study

open access: yesJournal of Advanced Nursing, EarlyView.
ABSTRACT Aim To conceptualise how ventilation‐related decisions are accomplished as interprofessional work in intensive care practice, moving beyond approaches that treat decision‐making as discrete events. Design Ethnography. Methods Data were generated through 97 h of participant observation and 17 episodic interviews with nurses (n = 12) and ...
Andreas Küpper   +5 more
wiley   +1 more source

Ventricular Tachycardia Ablation in Structural Heart Disease With LVEF > 35%: Clinical Outcomes and Recurrence Patterns

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT Background In patients with structural heart disease (SHD) and moderately impaired left ventricular ejection fraction (LVEF > 35%), data on outcomes after ventricular tachycardia (VT) ablation remain limited. This analysis focuses on VT recurrence after ablation in patients presenting with sustained VT and LVEF > 35% within a secondary ...
Said‐Elias Waezsada   +14 more
wiley   +1 more source

Early Onset Bacteremia in Kidney Transplant Recipients in the Current Era

open access: yesTransplant Infectious Disease, EarlyView.
ABSTRACT Background Bloodstream infection (BSI) after kidney transplantation increases the risk of graft loss and mortality. We aimed to identify contemporary risk factors and outcomes of early BSI (eBSI) at our transplant center. Methods We conducted a retrospective chart review of adult kidney transplant recipients (KTRs) from 2019 to 2023.
Lana Hasan   +6 more
wiley   +1 more source

Neonatal and pediatric extracorporeal membrane oxygenation in developing Latin American countries

open access: yesJornal de Pediatria
Objective: To review the principles of neonatal-pediatric extracorporeal membrane oxygenation therapy, prognosis, and its establishment in limited resource-limited countries in Latino America.
Javier Kattan   +3 more
doaj   +1 more source

Impact of Letermovir on Voriconazole Concentrations in Lung Transplant Patients

open access: yesTransplant Infectious Disease, EarlyView.
Concomitant letermovir was associated with lower voriconazole exposure and reduced attainment of commonly used efficacy thresholds in lung transplant recipients. Routine therapeutic drug monitoring after letermovir initiation is recommended, and empiric voriconazole dose escalation may be needed to avoid subtherapeutic exposure. ABSTRACT Background The
Leah Georgiades   +6 more
wiley   +1 more source

Transfusion of blood products to neonatal and pediatric extracorporeal membrane oxygenation patients: A prospective, observational study

open access: yesTransfusion, EarlyView.
Abstract Study Question To describe the blood product utilization during neonatal and pediatric extracorporeal membrane oxygenation (ECMO) and to determine whether its usage correlates with clinical outcomes of bleeding, thrombosis or mortality. Design Prospective observational study of neonatal and pediatric ECMO patients from September 2016, until ...
Rebecca Barton   +15 more
wiley   +1 more source

Ecological and Individual‐Level Factors Associated With Hantavirus Cardiopulmonary Syndrome Notifications and in‐Hospital Mortality Among Hospitalized Patients in Chile, 2005–2022

open access: yesZoonoses and Public Health, EarlyView.
ABSTRACT Introduction Hantavirus cardiopulmonary syndrome (HCPS) is a severe zoonotic disease caused by Orthohantavirus andesense (Andes virus, ANDV), with significant public health burden in Chile. Despite decades of surveillance, knowledge gaps remain regarding the ecological drivers of notification burden and the individual‐level determinants of in ...
Benjamín Diethelm‐Varela   +7 more
wiley   +1 more source

Society for Maternal‐Fetal Medicine Special Statement: Checklist for initial management of amniotic fluid embolism—Updated 2026

open access: yesPregnancy, Volume 2, Issue 5, September 2026.
Abstract Amniotic fluid embolism is a rare syndrome characterized by sudden cardiorespiratory collapse during labor or soon after delivery. Because of its rarity, many obstetrical providers have no experience in managing amniotic fluid embolism and may therefore benefit from a cognitive aid such as a checklist.
Society for Maternal‐Fetal Medicine (SMFM)   +6 more
wiley   +1 more source

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