Results 41 to 50 of about 8,740 (136)

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, Volume 13, Issue 43, 3 August 2026.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Evaluation of treatment parameters for focused-extracorporeal shock wave therapy in knee osteoarthritis patients with bone marrow lesions: a pilot study

Journal of Rehabilitation Medicine
Objectives: To evaluate the effect of different dosage parameters of focused-extracorporeal shock wave therapy on pain and physical function in knee osteoarthritis patients with bone marrow lesions.
Hani Al-Abbadi, Jacqueline E. Reznik, Erik Biros, Bruce Paulik, Rob Will, Samuel Gane, Penny Moss, Anthony Wright   +7 more
doaj   +1 more source

Procedure‐specific temperature dependence and lag structure of urinary stone surgery: A nationwide open‐data study in Japan, 2019–2024

BJUI Compass, Volume 7, Issue 8, August 2026.
Abstract Objectives To determine whether the seasonality of urinary stone surgery and its association with ambient temperature differ between surgical procedures and to compare the time lag between temperature and each procedure. Subjects and methods We used the nationwide open data of the National Database of health insurance claims in Japan for ...
Yuto Sakurai, Takashi Kawahara, Akihito Hashizume, Masanobu Yamazaki, Teppei Takeshima, Shinnosuke Kuroda, Tomoyuki Tatenuma, Hiroji Uemura, Kazuhide Makiyama, Jun‐ichi Teranishi   +9 more
wiley   +1 more source

Low-Intensity Extracorporeal Shock Wave as a Novel Treatment for Erectile Dysfunction

American Journal of Men's Health, 2016
The paradigm of erectile dysfunction (ED) treatment was fundamentally altered following the introduction of oral phosphodiesterase type 5 inhibitors.
Michael M. Pan MD, Ayman Raees MD, FRCSC, Jason R. Kovac MD, PhD, FRCSC   +2 more
doaj   +1 more source

Shockwave Therapy or Acupoint Stimulation Combined With Physiotherapy for Spasticity and Motor Function in Post‐Stroke Recovery: A Randomized Controlled Trial

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Stroke frequently causes spasticity and motor impairment, reducing independence. Non‐invasive treatments like radial extracorporeal shockwave therapy (ESWT) and acupoint‐based transcutaneous electrical nerve stimulation (Acu‐TENS) show potential, but direct comparisons with physiotherapy are limited.
Kazi Md Azman Hossain, Meer Hossain Hero, Mahomuda Afroze, Saddam Hossain, Md. Adnan Ibne Reza, Tofajjal Hossain, Ahamadullah Hil Galeb, Jannatul Ferdous Rikti, Mahdi Ul Bari, Arnob Datta   +9 more
wiley   +1 more source

Propofol‐Facilitated Recovery Sleep Modulates Cognitive Function via Slow Oscillation‐Spindle Coupling After Acute Sleep Deprivation in Rats

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
This study examined how propofol‐supported recovery sleep shapes cognitive and sleep‐EEG outcomes after 48‐h SD. Rats received Barnes maze, 2‐h and 24‐h NOR testing, cortical EEG/EMG recording, and NKCC1/KCC2 expression analysis. Propofol increased slow‐oscillation density and restored precise SO–spindle alignment, accompanied by a shift in NKCC1/KCC2 ...
Chenyi Yang, Huan Liu, Xinyi Wang, Lin Zhang, Haiyun Wang   +4 more
wiley   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE‐A Cohort of 1.2 Million Surgeries

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Postoperative complications substantially increase morbidity, mortality and healthcare costs. Understanding prognostic factors is essential for risk stratification, targeted prevention strategies, and development of prediction models.
Anders Peder Højer Karlsen, Asta Prescott, Caroline Folkersen, Jens Laigaard, Atena Saito, Caroline Lando Klammer, Mik Wetterslev, Emil Ipsen Ørskov, Mathilde Fahrendorff, Rebecca Kiær, Helene Holm Laigaard, Nichlas Hovmand, Lars Hyldborg Lundstrøm, Sebastian Buhl Rasmussen, Anders Kehlet Nørskov, Markus Harboe Olsen   +15 more
wiley   +1 more source

Effects of Extracorporeal Shock Wave Therapy in Pain Point on Range of Motion, Pain and Mechanical Muscle Properties in Myofascial Pain Syndrome

Physical Therapy Korea, 2021
Background: To evaluate whether extracorporeal shock wave therapy (ESWT) in the pain point is a more effective treatment than the trigger point for myofascial pain syndrome (MPS) of the upper trapezius.
Koo-Young Jung, Tae-Lim Yoon, Jun-Hee Lee   +2 more
doaj   +1 more source

eNOS Uncoupling, Shear‐Stress Tolerance, and the Two‐Threshold Model of Post‐Exertional Malaise in Long COVID: A Mechanistic Hypothesis With Implications for Physiotherapy and Recovery Protocols

Microcirculation, Volume 33, Issue 6, August 2026.
ABSTRACT Objective To propose and make testable a mechanistic hypothesis for post‐exertional malaise (PEM) in a clinically distinct subset of Long COVID patients, in whom delayed exertional symptoms coexist with consistently normal macrovascular investigations.
Yiannis K. Karipidis, Konstantinos Y. Karipidis   +1 more
wiley   +1 more source