Results 151 to 160 of about 2,690,163 (176)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Extraction Systems with Associated Extractants [PDF]

Russian Chemical Reviews, 1974
The review examines the characteristics of the extraction behaviour of extractants with pronounced self-association in the organic solution. The importance of the correct choice of the model of the liquid for an adequate description of the properties of the system is discussed. The bibliography includes 127 references.
V N Komarov, E V Komarov
openaire   +1 more source

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To extract or not to extract in secretin radioimmunoassay?

International journal of pancreatology, 1988
The importance of an ethanol extraction procedure in the radioimmunoassay of plasma secretin was investigated. The extraction step led to a higher assay sensitivity of 0.35 fmol/ml, compared to 5.93 fmol/ml using unextracted samples. The rise of plasma secretin after infusion of a low dose of secretin (1 pmol.kg-1.h-1) in 10 healthy humans was only ...
K. Gyr, Cornelia Schulthess, Christoph Beglinger, Brigitte Müller, Michael Fried   +4 more
openaire   +3 more sources

Extracts and Comments

Blackfriars, 1935
‘une belle equipe’ is the title of a stimulating account in the Canadian Revue Dominicaine of the work of the ‘Cerf’ publishing house in Paris:They are only seven Friars Preachers, but they control one of the most triumphant of the Catholic movements of France, that of ‘Les Editions du Cerf.’ True, they have the wholehearted support of many of their ...
openaire   +1 more source

Capillary Extraction

Langmuir, 2011
A nonwetting slug placed at the end of a capillary tube is unstable: a small displacement results in the complete extraction of the liquid from the tube. We study two limiting cases, corresponding to a slug viscosity larger or smaller than that of the surrounding liquid.
Piroird, Keyvan, Clanet, Christophe, Quéré, David   +2 more
openaire   +5 more sources

Information Extraction

2009
International ...
Nédellec, Claire, Nazarenko, Adeline, Bossy, Robert, R.   +2 more
openaire   +4 more sources

Extraction techniques

Analytical and Bioanalytical Chemistry, 2001
International ...
openaire   +5 more sources