Results 81 to 90 of about 133,410 (217)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Extraction and DFT Study on the Complexation of Zn2+ with Beauvericin

Acta Chimica Slovenica, 2014
From extraction experiments and γ-activity measurements, the exchange extraction constant corresponding to the equilibrium Zn2+(aq) + 1 . Sr2+(nb) ⇔1 .
Emanuel Makrlík, Petr Toman, Petr Vanŭra   +2 more
doaj  

Extraction of P11 resonances from pi N data

, 2010
We show that two P11 nucleon resonance poles near the pi Delta threshold, obtained in several analyses, are stable against large variations of parameters within a dynamical coupled-channels analysis based on meson-exchange mechanisms.
B. Juliá-Díaz, G. Höhler, H. Kamano, S. X. Nakamura, T. Sato, T.-S. H. Lee   +5 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Effective transmission conditions for Hamilton-Jacobi equations defined on two domains separated by an oscillatory interface

, 2015
We consider a family of optimal control problems in the plane with dynamics and running costs possibly discontinuous across an oscillatory interface $\Gamma_\epsilon$.
Achdou, Yves, Oudet, Salomé, Tchou, Nicoletta   +2 more
core   +4 more sources

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Phycocyanin ultrasound assisted extraction from Spirulina (Arthrospira platensis) using sodium phosphate buffer solvent: Mass transfer modelling and stability test

South African Journal of Chemical Engineering
Microalgae Spirulina (Arthrospira platensis) contains high protein content (55–70 %), consisting of approximately 20 % phycocyanin compounds as a photosynthetic pigment. Phycocyanin has antioxidant and anti-inflammatory properties.
Brilian Ryan Sadewo, Rochmadi, Nugroho Dewayanto, Eko Agus Suyono, Alinda Fitrotun Nisya, Amare Nirwasita Parafianto, Butsaina Masaroh Zulhan, Arief Budiman   +7 more
doaj   +1 more source

Complexation of Pr(Ⅲ) with Tetraalkyl Diglycolamides in Wet n-octanol, Aqueous Solution, Solid State and Solvent Extraction

Yuanzineng kexue jishu, 2022
To further understand the complexation of An(Ⅲ) and Ln(Ⅲ) with tetraalkyl diglycolamides (TRDGA), the complexation of Pr(Ⅲ) with water-insoluble N, N′-dimethyl-N,N′-dioctyl-diglycolamide (DMDODGA, L) and water-soluble tetramethyl-diglycolamide (TMDGA, L′)
YANG Suliang;ZHANG Yan;LIU Qian;KOU Fei;MA Siqi;TIAN Guoxin
doaj  

A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems

International Journal of Adaptive Control and Signal Processing, Volume 39, Issue 3, Page 566-581, March 2025.
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam, Anthony Siming Chen, Guido Herrmann   +2 more
wiley   +1 more source