Results 81 to 90 of about 1,270 (205)

An Evaluation of HER2 Expression Heterogeneity in Primary Tumors and Metastatic Lymph Nodes of Patients With Advanced Extramammary Paget's Disease: Prognostic and Therapeutic Implications

Cancer Medicine, Volume 14, Issue 19, October 2025.
ABSTRACT Background HER2 expression in primary versus metastatic tumors in advanced Extramammary Paget's Disease (EMPD) remains inadequately characterized. This investigation aimed to assess HER2 expression heterogeneity between primary tumors and metastatic lymph nodes (LNs) in patients with advanced EMPD and to assess the prognostic value of HER2 ...
Zhicheng Liu, Xingliang Tan, Zhiming Wu, Yi Tang, Qianghua Zhou, Wensu Wei, Cong Yang, Long Huang, Yanjun Wang, Kai Yao   +9 more
wiley   +1 more source

The evolving role of TRPS1 in dermatopathology: insights from the past 4 years [PDF]

Journal of Pathology and Translational Medicine
Over the past 4 years, trichorhinophalangeal syndrome type 1 (TRPS1) has rapidly gained attention among practicing pathologists, with numerous studies emerging that both support and question its diagnostic utility. Initially regarded as a highly specific
Mokhtar H. Abdelhammed, Woo Cheal Cho
doaj   +1 more source

Serum Nectin‐4 as a Potential Prognostic Biomarker for Extramammary Paget Disease

Experimental Dermatology, Volume 34, Issue 10, October 2025.
ABSTRACT Nectin cell adhesion molecule 4 (Nectin‐4) is overexpressed in the tissue of extramammary Paget disease (EMPD), and its potential role as a circulating biomarker remains poorly explored. We therefore investigated serum levels of Nectin‐4 in EMPD patients and healthy controls by ELISA assay and analysed its clinical relevance.
Hiromichi Morita, Takuya Miyagawa, Kenta Oka, Okuto Iwasawa, Hinako Saito, Toko Mori, Hisao Kawashima, Jun Omatsu, Daisuke Yamada, Shinichi Sato   +9 more
wiley   +1 more source

Perianal Pagetoid Intraepithelial Carcinoma

Case Reports in Gastroenterology, 2017
Extramammary Paget disease (EMPD) involving the perianal region is rare and challenging to manage. Primary EMPD involves stand-alone noninvasive lesions within the epidermis, while secondary EMPD involves phenotypically similar lesions derived from ...
Suanga Sisodia, Robin Boushey, Goo Lee, Celia Marginean, Marcio M. Gomes, Gaurav Bhattacharya, Kristopher Dennis   +6 more
doaj   +1 more source

An Asymptomatic Lesion on the Penis

JEADV Clinical Practice, Volume 5, Issue 1, Page 309-311, March 2026.
Brandon Tan, Karen Cheung, Xin Liu, Alexis Daniel Lara Rivero   +3 more
wiley   +1 more source

Comprehensive management of vulvovaginal cancers

CA: A Cancer Journal for Clinicians, Volume 75, Issue 5, Page 410-435, September/October 2025.
Abstract Vulvar and vaginal cancers represent rare malignancies, with an incidence of 2.7 per 100,000 women for vulvar cancer, predominantly affecting women older than 60 years, although rising rates are observed in younger demographics. Approximately 90% of vulvar cancers are squamous cell carcinoma and frequently are associated with human ...
Angélica Nogueira‐Rodrigues, Maaike H. M. Oonk, Domenica Lorusso, Brian Slomovitz, Mario M. Leitão Jr, Glauco Baiocchi   +5 more
wiley   +1 more source

External beam radiotherapy of extramammary Paget disease

, 2015
Extramammary Paget disease (EMPD) is an insidious intraepithelial neoplasm that is difficult to control with surgery, as large resections typically are required.
Gehrig, Anita, Tackenberg, Selma, Navarini, Alexander A, Dummer, Reinhard, Navarini, Alexander A.   +4 more
core  

A case of extramammary inguinal Paget disease in a male patient: surgical treatment with an abdominal advancement cutaneous flap [PDF]

, 2017
Extramammary Paget disease (EMPD) is a rare neoplasm. The clinical case of a 55-year-old man with a two-year history of a pruritic, painless erythematous skin rash on the inguinal region and scrotum is described.
Nisi G., Brandi C., Cuomo R., Sisti A., Tassinari J., D'Aniello C., Milonia L., Grimaldi L.   +7 more
core   +2 more sources

A case of extramammary Paget's disease

, 2018
Extramammary Paget's disease (EMPD) is a disorder that frequently affects the anogenital region in the elderly. Clinically, it presents a well circumscribed, reddish brown plaque.
명기범, 최혜영
core  

The Role of Radiotherapy in Extramammary Paget Disease: A Systematic Review

, 2018
Extramammary Paget disease (EMPD) is a rare neoplasm of the skin generally affecting the anogenital area. Because of the low-frequency of the disease, no specific guidelines about the treatment strategy are available.
Gui B, Gentileschi S, Casà C, Garganese G, Valentini V, Tagliaferri L, Pesce A, Inzani F, Autorino R, Morganti AG, Macchia G, Cammelli S, Perotti G, Gambacorta MA.   +13 more
core   +1 more source