Results 71 to 80 of about 69,180 (314)

Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 [PDF]

, 2014
Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely understood.
Akinc, Anna Borodovsky, Assmus, Auffray, Chow, Clinton, Coelho, Courties, Dahlman, Dai, Daniel G. Anderson, Ding, Ding, Dutta, Elices, Filip K. Swirski, Florian Leuschner, Frank-Kamenetsky, Friedrich Felix Hoyer, Gabriel Courties, Gregory Wojtkiewicz, Hendrik B. Sager, Hume, Kevin Fitzgerald, Kiel, Kim, Leuschner, Leuschner, Love, Lu, Lubov S. Grigoryeva, Majmudar, Massa, Matthias Nahrendorf, Miyake, Moore, Murphy, Nahrendorf, Nicolas Da Silva, Novobrantseva, Panizzi, Partha Dutta, Peter Libby, Qiao, Rajavashisth, Ralph Weissleder, Rauch, Robbins, Robbins, Rosas, Salomon, Scott, Shaposhnik, Sugiyama, Swirski, Swirski, Swirski, Tagliani, Takahashi, Takizawa, Tatiana Novobrantseva, Trogan, Tsujioka, Ulyanova, van Gils, Vera M. Ruda, Wang, Williams, Winkler, Yona, Yoshiko Iwamoto, Yuan Sun   +71 more
core   +2 more sources

Extramedullary hematopoiesis in the absence of myeloproliferative neoplasm: Mayo Clinic case series of 309 patients

Blood Cancer Journal, 2018
Background : Extramedullary hematopoiesis (EMH) implies the production of erythroid and myeloid progenitor cells outside of the bone marrow. EMH in adults is typically seen in patients with myeloproliferative neoplasms (MPN).
N. Fan, S. Lavu, C. Hanson, A. Tefferi
semanticscholar   +1 more source

Multifocal extramedullary hematopoiesis in a 15-year-old girl with beta thalassemia: A case report

Radiology Case Reports, 2022
Extramedullary hematopoiesis is a rare disorder in which hematopoietic cells proliferate in tissues other than the bone marrow as a result of a range of hematologic illnesses.
Hind Sahli, MD., Jihad Boularab, MD., Jihane El Mandour, MD., Nazik Allali, MD, Ph-D., Latifa Chat, MD, Ph-D., Siham El Haddad, MD, Ph-D.   +5 more
doaj  

Thoracic extramedullary hematopoiesis: a rare clinical image. [PDF]

Pan Afr Med J
Karnan A, Ledwani A.
europepmc   +2 more sources

Ames hypopituitary dwarf mice demonstrate imbalanced myelopoiesis between bone marrow and spleen [PDF]

, 2015
Ames hypopituitary dwarf mice are deficient in growth hormone, thyroid-stimulating hormone, and prolactin. The phenotype of these mice demonstrates irregularities in the immune system with skewing of the normal cytokine milieu towards a more anti ...
Bartke, Andrzej, Broxmeyer, Hal E., Capitano, Maegan L., Chitteti, Brahmananda R., Cooper, Scott, Srour, Edward F.   +5 more
core   +1 more source

Bayesian inference and model choice in a hidden stochastic two-compartment model of hematopoietic stem cell fate decisions [PDF]

Annals of Applied Statistics 2009, Vol. 3, No. 4, 1695-1709, 2010
Despite rapid advances in experimental cell biology, the in vivo behavior of hematopoietic stem cells (HSC) cannot be directly observed and measured. Previously we modeled feline hematopoiesis using a two-compartment hidden Markov process that had birth and emigration events in the first compartment.
arxiv   +1 more source

Extramedullary Hematopoiesis: An Unusual Finding in Subdural Hematomas

Case Reports in Pathology, 2011
We present a case of a 59-year-old man who was found to have clusters of hyperchromatic, small, round nucleated cells within a subdural hematoma removed after a skull fracture.
Rong Li, Vishnu V. B. Reddy, Cheryl Ann Palmer   +2 more
doaj   +1 more source

The Role of MCPIP1 in Macrophage Polarization and Cardiac Function Post‐Myocardial Infarction

Advanced Science, EarlyView.
Following myocardial infarction, MCPIP1 deficiency in macrophages triggers ferroptosis, driving proinflammatory M1 dominance over reparative M2 phenotypes. This imbalance amplifies splenic monocyte release and sustains cardiac inflammation. Concurrently, excessive inflammatory mediators and insufficient TGF‐β impair fibroblast activation, delaying ...
Xingxu Zhang, Yuan Fang, Xiaoming Qin, Yiwei Zhang, Bo Kang, Li Zhong, Baoxin Liu, Jiachen Luo, Yidong Wei   +8 more
wiley   +1 more source

Niche-induced extramedullary hematopoiesis in the spleen is regulated by the transcription factor Tlx1

Scientific Reports, 2018
Extramedullary hematopoiesis (EMH) in postnatal life is a pathological process in which the differentiation of hematopoietic stem/progenitor cells (HSPCs) occurs outside the bone marrow (BM) to respond to hematopoietic emergencies.
Akihisa Oda, Toshiki Tezuka, Y. Ueno, Shoko Hosoda, Yusuke Amemiya, Chihiro Notsu, Toru Kasahara, C. Nishiyama, R. Goitsuka   +8 more
semanticscholar   +1 more source

Comparative pathogenicity of vaccinia virus and mpox virus infections in CAST/EiJ mice: Exploring splenomegaly and transcriptomic profiles

Animal Models and Experimental Medicine, EarlyView.
We successfully constructed CAST/EiJ mice models infected with low‐dose vaccinia virus (VACV‐L), high‐dose VACV (VACV‐H), and mpox virus (MPXV), demonstrating that VACV‐L and MPXV infections induced splenomegaly in mice, and VACV‐H infection caused mortality in mice.
Yongzhi Hou, Jianrong Ma, Baoying Huang, Na Li, Lin Zhu, Ziqing Jia, Jiasen Yang, Jingjing Zhang, Wenjie Tan, Jing Xue   +9 more
wiley   +1 more source