Results 81 to 90 of about 5,798,809 (203)

Contrast Agents for Enhanced Bioimaging: A Comprehensive Review

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Contrast agents, especially those that are nanoparticle‐based, are revolutionizing bioimaging by enabling highly sensitive, specific, and early‐stage diagnosis of diseases like cancer, using clinical imaging modalities such as CT, MRI, PET, and SPECT.
Paulo Sérgio Taube, Donald Fernandes, Arthur Abinader Vasconcelos, Hugo de Campos Braga, Alan Kelbis Oliveira Lima, José Arnaldo Santana Costa, Karla Furtado Andriani, Ester da Cunha Meira Santos, Antonio Jorge Silva Araújo Junior, Hauster Maximiler Campos de Paula, Wallace Júnio Reis, Kashif Gul, Nida Wahab, Luis Carlos Resio, Elisa Kawana Leal dos Santos, Márcio Peres de Araujo, Matheus Allen P. da Silva, Juliana Paula da Silva   +17 more
wiley   +1 more source

The Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of Zongertinib in Healthy Male Volunteers

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 7, July 2026.
ABSTRACT Introduction Zongertinib is an irreversible tyrosine kinase inhibitor that selectively inhibits human epidermal growth factor receptor 2 (HER2) while sparing wild‐type epidermal growth factor receptor (EGFR), thereby minimizing associated toxicities. Oxidative hepatic metabolism of zongertinib in vitro is principally driven by cytochrome P450 (
Owen Scudamore, Sven Wind, Rolf Grempler, Habib Esmaeili, Fabian Müller   +4 more
wiley   +1 more source

Reliability of extravascular lung thermal volume measurements by thermal conductivity technique in sheep

, 1992
We tested the accuracy, sensitivity, and reproducibility of a new lung water computer, based on the thermal conductivity technique, in 22 anesthetized closed-chest ventilated sheep with different treatments: 1) controls (n = 8), 2) 0.05 ml/kg of oleic ...
V. B. Serikov, K. Kambara, N. C. Staub, E. H. Jerome, M. Arakawa   +4 more
core   +1 more source

Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Marylore Chenel, Andre Dallmann, Ibrahim Ince, Michaela Meyer, Jan‐Frederik Schlender, Donato Teutonico, Erik Sjögren   +6 more
wiley   +1 more source

Extravascular lung water measurement using transpulmonary thermodilution in children. [PDF]

, 2009
Contains fulltext : 80712.pdf (Publisher’s version ) (Open Access)OBJECTIVE: Measurement of extravascular lung water (EVLW) may be useful in the treatment of critically ill children and can be performed at the bedside using the ...
Lemson, J., Backx, A.P.C.M., Oort, A.M. van, Bouw, M.P.W.J.M., Hoeven, J.G. van der   +4 more
core   +1 more source

Postperfusion lung syndrome: Respiratory mechanics, respiratory indices and biomarkers

Annals of Thoracic Medicine, 2015
Postperfusion lung syndrome is rare but lethal. Secondary inflammatory response was the popularly accepted theory for the underlying etiology. Respiratory index (RI) and arterial oxygen tension/fractional inspired oxygen can be reliable indices for the ...
Shi-Min Yuan
doaj   +1 more source

Extravascular lung water indexed to predicted body weight is a novel predictor of intensive care unit mortality in patients with acute lung injury

, 2010
Objectives: Acute lung injury and the acute respiratory distress syndrome are characterized by noncardiogenic pulmonary edema, which can be assessed by measurement of extravascular lung water.
Craig, T.R., Duffy, M.J., Elborn, Joseph, McLaughlin, B., McAuley, Danny; id_orcid, Shyamsundar, M., McDowell, C.   +6 more
core   +1 more source

Dynamics of Extravascular Pulmonary Water and Intracranial Pressure in Patients With Ischemic Stroke

, 2010
The objective of the present study was to examine the relationship among extravascular pulmonary water, intracranial and cerebral perfusion pressure, hemodynamic parameters (eg, cardiac index, system vascular resistance index), and brain stem function ...
Mikhail Verein, Pavel Sitnikov, Larisa Redkokasha, Yuri Churliaev, Azat Valiahmedov, Konstantine Lukashev   +5 more
core   +1 more source

MECHANISMS OF SECONDARY BRAIN DAMAGE IN COMA DEVELOPED IN ACUTE PERIOD OF ISCHEMIC STROKE

Медицина в Кузбассе, 2017
The study of mechanisms of secondary brain damage in coma developedin acute period of ischemic stroke is essential for providing differentiated intensive therapy and disease outcome. However, this issue is not considered in workspublished.
Константин Владимирович Лукашев, Юрий Алексеевич Чурляев, Олег Геральдович Фомкин, Сергей Людовикович Кан, Лариса Юрьевна Редкокаша, Андрей Александрович Косовских   +5 more
doaj  

Influence of thoracic epidural anesthesia to extravascular lung water, haemodynamic changes and postoperative time during on-pump cardiac surgery [PDF]

, 2010
Thoracic epidural anaesthesia, directly influencing blood circulation in a small circle of blood circulation, definitely has impact on amount of a liquid in a lung interstitial tissue (amount of extravascular lung water).
Lenkutis, Tadas
core