Results 61 to 70 of about 717,463 (328)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Spatial-temporal dynamics of population exposure to compound extreme heat-precipitation events under multiple scenarios for Pearl River Basin, China

Climate Services
Extreme heat-precipitation events, such as heatwaves and extreme precipitation, can have substantial impacts on the population, particularly in urbanized watersheds.
Zixuan Qi, Lian Sun, Yanpeng Cai, Yulei Xie, Linlin Yao, Bowen Li, Yuchen Ye   +6 more
doaj   +1 more source

Climate Dynamics: A Network-Based Approach for the Analysis of Global Precipitation [PDF]

, 2013
Precipitation is one of the most important meteorological variables for defining the climate dynamics, but the spatial patterns of precipitation have not been fully investigated yet. The complex network theory, which provides a robust tool to investigate
A Becker, A Gozolchiani, A Kolzsch, AA Tsonis, AA Tsonis, AA Tsonis, AJ Simmons, Alex J. Cannon, AS Cofiño, B Rajagopalan, C Chou, D Hemming, DJ Watts, DL Montroy, DR Archer, F Raicich, Francesco Laio, GJ McCabe, GJ van Oldenborgh, J Heitzig, J Kennedy, J Kennedy, J Kennedy, J Shaman, JE Hansen, JF Diaz, JF Donges, JF Donges, JF Donges, JM Ryoo, JP Boulanger, JW Hurrell, K Steinhaeuser, K Yamasaki, KF Davis, LC Freeman, LD Costa, LD Costa, LL Chen, Luca Ridolfi, M Fritsche, M Palus, MEJ Newman, N Malik, R Albert, R Cano, RH Kripalani, S Abe, S Boccaletti, S Brönnimann, S Fatichi, S Michaelides, S Saeed, SE Nicholson, Stefania Scarsoglio, T Zhou, U Gessner, U Schneider, V Petoukhova, W Chen   +59 more
core   +4 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Quantifying hazard of drought and heat compound extreme events during maize (Zea mays L.) growing season using Magnitude Index and Copula

Weather and Climate Extremes, 2023
Hazard assessment is the basic work in the field of disaster risk. For the agricultural field which is seriously affected by extreme events, it is necessary to carry out hazard assessment of compound extreme events (CEEs) to increase the accuracy of risk
Ying Guo, Jiquan Zhang, Kaiwei Li, Han Aru, Zhi Feng, Xingpeng Liu, Zhijun Tong   +6 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Adapting to climate change through anticipatory action: The potential use of weather-based early warnings

Weather and Climate Extremes, 2022
As a crucially-needed adaptation to climate change, the United Nations plans to expand Early Warning Systems (EWS) for extreme weather to cover everyone on Earth.
Erin Coughlan de Perez, Laura Harrison, Kristoffer Berse, Evan Easton-Calabria, Joalane Marunye, Makoala Marake, Sonia Binte Murshed, Shampa, Erlich-Honest Zauisomue   +8 more
doaj   +1 more source

Hospital Capacity Data and Extreme Heat Event Vulnerability

JAMA Network Open
This qualitative study examines how regional health care capacity is associated with extreme heat event vulnerability.
Mahmoud, Hussam, Gadgil, Meghana, Hassan, Emad M., Martin, Michael, Castillo, Enrico G., Diem, Stephanie, Krieger, Elena   +6 more
openaire   +2 more sources