Results 81 to 90 of about 3,283,373 (332)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Space–Time Characterization of Extreme Precipitation Indices for the Semiarid Region of Brazil

Climate
Various indices of climate variability and extremes are extensively employed to characterize potential effects of climate change. Particularly, the semiarid region of Brazil is influenced by adverse effects of these changes, especially in terms of ...
Ana Letícia Melo dos Santos, W. A. Gonçalves, Lára de Melo Barbosa Andrade, D. Rodrigues, Flávia Ferreira Batista, Gizelly Cardoso Lima, Cláudio Silva   +6 more
semanticscholar   +1 more source

Trends in extreme daily precipitation indices in Bosnia and Herzegovina [PDF]

, 2017
The study investigates trends in extreme daily precipitation indices in Bosnia and Herzegovina. A set of daily precipitation time series from four meteorological stations was used for the computation of 13 indices (mostly recommended by the ETCCDI ...
Trbić Goran, Gnjato Slobodan, Ivanišević Marko, Popov Tatjana   +3 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

GTI-space : the space of generalized topological indices [PDF]

, 2008
A new extension of the generalized topological indices (GTI) approach is carried out torepresent 'simple' and 'composite' topological indices (TIs) in an unified way.
Matamala, Adelio R., Estrada, Ernesto, Ramon y Cajal program Spain (Funder)   +2 more
core   +4 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Scaling in long term data sets of geomagnetic indices and solar wind ϵ as seen by WIND spacecraft [PDF]

, 2003
We study scaling in fluctuations of the geomagnetic indices (AE, AU, and AL) that provide a measure of magnetospheric activity and of the ε parameter which is a measure of the solar wind driver.
Chapman, S.C., Freeman, M. P. (Mervyn P.), Freeman, M.P., Hnat, B., Rowlands, G., Watkins, N.W., Rowlands, G. (George), Watkins, Nicholas W., Chapman, Sandra C.   +8 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Recent changes in Serbian climate extreme indices from 1961 to 2010

Theoretical and Applied Climatology, 2016
The evolution of daily extreme temperature and precipitation from 1961 to 2010 in Serbia was investigated. Trends of five temperature indices, three precipitation indices, and four combined indices were calculated at ten temperature and ten precipitation
Slavica Malinović-Milićević, M. Radovanović, G. Stanojević, B. Milovanović   +3 more
semanticscholar   +1 more source