Precipitation extremes are expected to intensify due to an increased moisture holding capacity in the atmosphere with higher temperatures; according to the Clausius–Clapeyron (CC) relation this increase is approximately 7% for every degree increase in ...
Conrad Wasko +2 more
doaj +1 more source
Movement Disorders in Aicardi–Goutières Syndrome and Response to Immunomodulation
ABSTRACT This study characterizes movement disorders and treatment responses in seven children with Aicardi–Goutières syndrome (AGS). We retrospectively evaluated motor phenotypes, neuroimaging, and interferon signatures in patients treated with baricitinib or anifrolumab. Spasticity affected all patients, while dystonia was present in 4/7.
Enrique Gonzalez Saez‐Diez +10 more
wiley +1 more source
TESTING THE EXISTENCE OF CLUSTERING IN THE EXTREME VALUES [PDF]
This paper introduces an estimator for the extremal index as the ratio of the number of elements of two point processes defined by threshold sequences un, vn and a partition of the sequence in different blocks of the same size. The first point process is
Jose Olmo
core +2 more sources
Asymptotic farthest points and extreme points
Let X be a normed space, G a nonempty bounded subset of X and fxng a bounded sequence in X. In this article, we introduce and discuss the concept of asymptotic farthest points of fxng in G, which is a new definition in abstract approximation theory.
Ardakani, M. Zare Nejhad +1 more
openaire +3 more sources
Compound Heterozygote Friedreich Ataxia Patients With Covert Proximal FXN Gene Deletions
ABSTRACT We present Friedreich ataxia patients with frataxin gene deletions. Data and records were collected at the Children's Hospital of Philadelphia from patients enrolled in the FACOMS natural history study. Patients with proximal deletions initially diagnosed with only one GAA expanded allele had more severe disease than their homozygous expansion
Michael P. Lazaropoulos +5 more
wiley +1 more source
Generalized Extreme Value Distribution with Time-Dependence Using the AR and MA Models in State Space Form [PDF]
A new state space approach is proposed to model the time- dependence in an extreme value process. The generalized extreme value distribution is extended to incorporate the time-dependence using a state space representation where the state variables ...
Jouchi Nakajima +3 more
core
Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin +11 more
wiley +1 more source
Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle +4 more
wiley +1 more source
Experimental investigation of an interior search method within a simple framework
A steepest gradient method for solving Linear Programming (LP) problems, followed by a procedure for purifying a non-basic solution to an improved extreme point solution have been embedded within an otherwise simplex based optimiser.
Mitra, G, Yadeger, J, Tamiz, M
core
Extreme points, strongly extreme points and exposed points in Orlicz--Lorentz spaces
In this paper, we investigate the extremal structure of the unit ball in the most general classes of Orlicz--Lorentz spaces. the characterizations of extreme points, strongly extreme points, and exposed points are given for Orlicz--Lorentz function spaces $Λ_{φ,ω}$ generated by an arbitrary Orlicz function $φ$ and a non--increasing weight function $ω$,
Wang, Di., Li, Yongjin.
openaire +2 more sources

