Results 41 to 50 of about 3,018,746 (236)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Spanish extreme right and the Internet

, 2011
O artigo investiga o papel potencial da internet para as organizações espanholas de extrema-direita, tendo em vista o estabelecimento de contactos (a nível nacional e internacional), a promoção da identidade colectiva e a mobilização. Para analisar este tema, o artigo combina a metodologia qualitativa e quantitativa.
Caiani, Manuela, Parenti, Linda
openaire   +5 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Book review: the extreme gone mainstream: commercialisation and far right youth culture in Germany by Cynthia Miller-Idriss [PDF]

, 2018
In The Extreme Gone Mainstream: Commercialisation and Far Right Youth Culture, Cynthia Miller-Idriss explores how far-right ideology has infiltrated contemporary mainstream German culture through commercial products that are coded with extremist messages.
Williams, Katherine
core   +5 more sources

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Why is there no radical right party in Ireland? [PDF]

, 2008
The rise of the radical or extreme right parties in Europe - parties usually noted for strong, sometimes racist anti-immigrant ideologies - has attracted a great deal of attention in political science.
O'Malley, Eoin
core   +2 more sources

The Extreme Right as a Defender of Human Rights? Parliamentary Debates on COVID-19 Emergency Legislation in Slovakia

Laws, 2022
During the COVID-19 pandemic, the protection of public health became a political priority worldwide. Slovakia’s COVID-19 response was initially praised as a global success.
Max Steuer
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Identifying extreme-right terrorism

, 2022
Extreme-right terrorism is a threat that is often underestimated by the public at large. As this paper argues, this is partly due to a concept of terrorism utilized by policymakers, intelligence agents, and police investigators that is based on ...
Botsch, Gideon (apl. Prof. Dr. phil.)
core   +1 more source