Results 61 to 70 of about 722,943 (291)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Numerical Modeling of Extreme Sea Levels on the Laptev Sea Coast

Geosciences
The present study is devoted to the analysis of extreme sea level oscillations of the Laptev Sea using the ADCIRC model. The numerical modeling is performed on a high-resolution grid and verified for sea level observations from three tide gauges. We have
Mikhail E. Kulikov, Victor S. Arkhipkin, Igor P. Medvedev, Sergey A. Kovachev, Artem A. Krylov   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nonstationary Extreme Value Analysis of Nearshore Sea-State Parameters under the Effects of Climate Change: Application to the Greek Coastal Zone and Port Structures

Journal of Marine Science and Engineering, 2021
In the present work, a methodological framework, based on nonstationary extreme value analysis of nearshore sea-state parameters, is proposed for the identification of climate change impacts on coastal zone and port defense structures.
Panagiota Galiatsatou, Christos Makris, Yannis Krestenitis, Panagiotis Prinos   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Climate Change in the Piscataqua/Great Bay Region: Past, Present, and Future [PDF]

, 2011
Earth ’s climate changes. It always has and always will. However, an extensive body of scientific evidence indicates that human activities are now a significant force driving change in the Earth’s climate system.
Burakowski, Elizabeth, Douglas, Ellen, Hayhoe, Katharine, Kelsey, Eric, Stoner, Anne, Wake, Cameron P., Watson, Chris   +6 more
core   +1 more source

North Atlantic storm driving of extreme wave heights in the North Sea [PDF]

, 2017
The relationship between storms and extreme ocean waves in the North Sea is assessed using a long-period wave dataset and storms identified in the Interim ECMWF Re-Analysis (ERA-Interim). An ensemble sensitivity analysis is used to provide information on
Baker, Bidlot, Breivik, Browning, Browning, Camus, Cardone, Cavaleri, Clark, Dacre, Dacre, Dee, Feser, Garcies, Gemmrich, Gibson, Hanafin, Hewson, Hodges, Hodges, Hoskins, Kudryavtsev, Leadbetter, Martínez-Alvarado, Martínez-Alvarado, Odell, Ortiz-Royero, Pingree-Shippee, Pinto, Ponce de León, Reistad   +30 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Role of surface rainfall to the variability of extreme sea level along the eastern coast of Bangladesh

Natural Hazards Research
Bangladesh is highly vulnerable to the adverse impacts of extreme sea levels (ESLs) because of its geographical location with low-lying coast. In addition, high discharge of huge rain water to the nearby coast may influence the ESL.
Md. Anowarul Islam
doaj   +1 more source

Extreme Sea Level Estimation Combining Systematic Observed Skew Surges and Historical Record Sea Levels

Water Resources Research, 2022
AbstractThe estimation of sea levels corresponding to high return periods is crucial for coastal planning and for the design of coastal defenses. This paper deals with the use of historical observations, that is, events that occurred before the beginning of the systematic tide gauge recordings, to improve the estimation of design sea levels.
Laurie Saint Criq, Eric Gaume, Yasser Hamdi, Taha B. M. J. Ouarda   +3 more
openaire   +2 more sources