Results 51 to 60 of about 27,022,553 (300)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

State space modelling of extreme values with particle filters [PDF]

, 2009
State space models are a flexible class of Bayesian model that can be used to smoothly capture non-stationarity. Observations are assumed independent given a latent state process so that their distribution can change gradually over time. Sequential Monte
Wyncoll, David P.
core   +4 more sources

Increased intensity and frequency of extreme precipitation events in Belgium as simulated by the regional climate model MAR

Journal of Hydrology: Regional Studies
Study region: BelgiumStudy focus: In July 2021, Western Germany, the Netherlands and Belgium were hit by extreme rainfall events of unprecedented intensity, raising concerns about future trends.
Josip Brajkovic, Xavier Fettweis, Brice Noël, Hans Van De Vyver, Nicolas Ghilain, Pierre Archambeau, Michel Pirotton, Sébastien Doutreloup   +7 more
doaj   +1 more source

Spatial and Temporal Clustering Analysis of Extreme Wave Events around the UK Coastline

Journal of Marine Science and Engineering, 2017
Densely populated coastal regions are vulnerable to extreme wave events, which can cause loss of life and considerable damage to coastal infrastructure and ecological assets. Here, an event-based analysis approach, across multiple sites, has been used to
Victor Malagon Santos, Ivan D. Haigh, Thomas Wahl   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Nonstationary extreme value analysis of temperature extremes in China [PDF]

Stochastic Environmental Research and Risk Assessment, 2017
In a changing climate, the common assumption of stationarity of climate extremes has been increasingly challenged, raising the need to incorporate non-stationarity in extreme value modeling. In this study, quantile regression is used to identify the trends of annual temperature extremes and their correlations with two large climate patterns, the ...
Meng Gao, Hongzhen Zheng
openaire   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Characteristics of Extreme Value Statistics of Annual Maximum Monthly Precipitation in East Asia Calculated Using an Earth System Model of Intermediate Complexity

Atmosphere, 2020
Extreme precipitation is no longer stationary under a changing climate due to the increase in greenhouse gas emissions. Nonstationarity must be considered when realistically estimating the amount of extreme precipitation for future prevention and ...
Tosiyuki Nakaegawa, Takuro Kobashi, Hirotaka Kamahori   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source