Results 51 to 60 of about 28,836,462 (296)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Exposure Indices of Extreme Wind-Driven Rain Events for Built Heritage

Atmosphere, 2020
Building performance and material change of cultural heritage in urban areas are negatively impacted by wind-driven rain (WDR). The frequency and intensity of WDR exposure are modified by climate change.
Scott Allan Orr, May Cassar
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Applying Quantum Mechanics for Extreme Value Prediction of VaR and ES in the ASEAN Stock Exchange

Economies, 2021
The advantage of quantum mechanics to shift up the ability to econometrically understand extreme tail losses in financial data has become more desirable, especially in cases of Value at Risk (VaR) and Expected Shortfall (ES) predictions.
Chukiat Chaiboonsri, Satawat Wannapan
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Increased intensity and frequency of extreme precipitation events in Belgium as simulated by the regional climate model MAR

Journal of Hydrology: Regional Studies
Study region: BelgiumStudy focus: In July 2021, Western Germany, the Netherlands and Belgium were hit by extreme rainfall events of unprecedented intensity, raising concerns about future trends.
Josip Brajkovic, Xavier Fettweis, Brice Noël, Hans Van De Vyver, Nicolas Ghilain, Pierre Archambeau, Michel Pirotton, Sébastien Doutreloup   +7 more
doaj   +1 more source

Comparison of Extreme Wind and Waves Using Different Statistical Methods in 40 Offshore Wind Energy Lease Areas Worldwide

Energies, 2023
With the ongoing global drive towards renewable energy, several potential offshore wind energy lease areas worldwide have come into focus. This study aims to estimate the extreme wind and wave conditions across several newly designated offshore wind ...
Saravanan Bhaskaran, Amrit Shankar Verma, Andrew J. Goupee, Subhamoy Bhattacharya, Amir R. Nejad, Wei Shi   +5 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Nonstationary extreme value analysis of temperature extremes in China [PDF]

Stochastic Environmental Research and Risk Assessment, 2017
In a changing climate, the common assumption of stationarity of climate extremes has been increasingly challenged, raising the need to incorporate non-stationarity in extreme value modeling. In this study, quantile regression is used to identify the trends of annual temperature extremes and their correlations with two large climate patterns, the ...
Meng Gao, Hongzhen Zheng
openaire   +1 more source