Results 51 to 60 of about 237,312 (263)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Instantons and extreme value statistics of random matrices [PDF]

open access: yesJournal of High Energy Physics, 2014
30 pages, 4 figures, improved discussion, results unchanged, as ...
Atkin, Max R., Zohren, Stefan
openaire   +3 more sources

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Football fever: self-affirmation model for goal distributions

open access: yesCondensed Matter Physics, 2009
The outcome of football games, as well as matches of most other popular team sports, depends on a combination of the skills of players and coaches and a number of external factors which, due to their complex nature, are presumably best viewed as random ...
W. Janke   +3 more
doaj   +1 more source

A simple model for predicting the statistics of spatiotemporal extremes of sub-daily precipitation

open access: yesWeather and Climate Extremes, 2022
For a single site (of a rain gauge, say), the statistics of extreme precipitation are conveniently summarized by depth-duration-frequency (DDF) curves.
Cees de Valk, Aart Overeem
doaj   +1 more source

Hitting time statistics and extreme value theory [PDF]

open access: yesProbability Theory and Related Fields, 2009
We consider discrete time dynamical systems and show the link between Hitting Time Statistics (the distribution of the first time points land in asymptotically small sets) and Extreme Value Theory (distribution properties of the partial maximum of stochastic processes). This relation allows to study Hitting Time Statistics with tools from Extreme Value
Freitas, Ana Cristina Moreira   +2 more
openaire   +3 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Simultaneous tail index estimation

open access: yesRevstat Statistical Journal, 2004
The estimation of the extreme-value index γ based on a sample of independent and identically distributed random variables has received considerable attention in the extreme-value literature.
Jan Beirlant , Yuri Goegebeur
doaj   +1 more source

Extreme Value Statistics Distributions in Spin Glasses [PDF]

open access: yesPhysical Review Letters, 2011
We study the probability distribution of the pseudo-critical temperature in a mean-field and in a short-range spin-glass model: the Sherrington-Kirkpatrick (SK) and the Edwards-Anderson (EA) model. In both cases, we put in evidence the underlying connection between the fluctuations of the pseudo-critical point and and the Extreme Value Statistics of ...
Castellana, Michele   +2 more
openaire   +3 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

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